Efecto de Combigan® versus placebo en el flujo sanguíneo ocular en pacientes hipertensos oculares

  1. B. Puerto-Hernández
  2. G. Rebolleda
  3. J.L. García-Pérez
  4. F.J. Muñoz-Negrete
  5. C. González-Gordaliza
Revista:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Año de publicación: 2011

Volumen: 86

Número: 2

Páginas: 42-46

Tipo: Artículo

DOI: 10.1016/J.OFTAL.2010.07.005 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Archivos de la Sociedad Española de Oftalmologia

Resumen

Propósito: Estudiar los cambios hemodinámicos retrobulbares mediante ecografía doppler color, en pacientes hipertensos oculares (HTO) en tratamiento con Combigan® versus placebo. Método: Treinta pacientes randomizados en 2 grupos paralelos fueron incluidos en un estudio prospectivo y a doble ciego; quince de ellos en tratamiento con Combigan® y quince en tratamiento con placebo, durante un periodo de 3 meses. Se obtuvieron medidas de la presión intraocular (PIO) y del flujo sanguíneo a nivel de la arteria central de la retina (ACR) y la arteria oftámica en el momento basal y a los 3 meses. Resultados: Combigan® redujo significativamente la PIO tras tres meses de tratamiento (p=0,001). Los parámetros hemodinámicos basales fueron similares entre los grupos placebo y tratamiento. Los pacientes tratados con Combigan® mostraron un descenso estadísticamente significativo del índice de resistencia de la ACR (p=0,007). Conclusiones: Los pacientes tratados durante 3. meses con Combigan® mostraron un descenso estadísticamente significativo del índice de resistenciade la ACR que podría explicarse por el descenso de PIO.

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Fuente de los datos: Dialnet