Regioselective Ring-Opening Metathesis-Cross Metathesis of Bridgehead-Substituted 7-Azanorbornene
- Carreras, J. 1
- Avenoza, A. 1
- Busto, J.H. 1
- Peregrina, J.M. 1
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1
Universidad de La Rioja
info
ISSN: 1523-7060
Année de publication: 2007
Volumen: 9
Número: 7
Pages: 1235-1238
Type: Article
D'autres publications dans: Organic Letters
Résumé
Figure presented In this paper we describe a highly regioselective ring-opening metathesis-cross metathesis (ROM-CM) process between methyl N-Boc-7-azabicyclo[2.2.1]hept-2-en-1-carboxylate, a bridgehead-substituted 7-azanorbornene system, and electron-poor olefins. The reaction opens the way to the synthesis of interesting α-amino diacids and pyrrolizinone derivatives that incorporate quaternary stereocenters. © 2007 American Chemical Society.