Diseño, interacción y síntesis de compuestos biológicamente activos - Design, interaction and synthesis of bioactive compounds.
DISCOBAC


University of Bologna
Bolonia, ItaliaPublications in collaboration with researchers from University of Bologna (10)
2019
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Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment
European Journal of Medicinal Chemistry, Vol. 178, pp. 243-258
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Quinoxalinetacrine QT78, a cholinesterase inhibitor as a potential ligand for Alzheimer’s disease therapy
Molecules, Vol. 24, Núm. 8
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Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase
European Journal of Medicinal Chemistry, Vol. 167, pp. 161-186
2018
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Exploiting the chalcone scaffold to develop multifunctional agents for Alzheimer’s disease
Molecules, Vol. 23, Núm. 8
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Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 155, pp. 839-846
2017
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5-Methyl-: N -(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5 H -indolo[2,3- b] quinolin-11-amine: A highly potent human cholinesterase inhibitor
MedChemComm, Vol. 8, Núm. 6, pp. 1307-1317
2016
2012
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Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine
European Journal of Medicinal Chemistry, Vol. 52, pp. 251-262
2011
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Chemical and pharmacological studies on enantiomerically pure p-methoxytacripyrines, promising multi-target-directed ligands for the treatment of Alzheimer's disease
ChemMedChem, Vol. 6, Núm. 11, pp. 1990-1997
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Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues
European Journal of Medicinal Chemistry, Vol. 46, Núm. 12, pp. 6119-6130