Effects of locally applied Insulin-like Growth Factor-I on osseointegration

  1. Juan López Quiles 1
  2. Alba Forteza-López 2
  3. Mónica Montiel 3
  4. Celia Clemente de Arriba 4
  5. Jesús A. Fernández-Tresguerres Hernández 5
  6. Isabel Fernández Tresguerres 1
  1. 1 Associate Professor. MD, PhD, DDS. Department of Dental Clinical Specialities, School of Dentistry, Complutense University. Madrid, Spain
  2. 2 Postgraduate student. DDS. Department of Dental Clinical Specialities, School of Dentistry, Complutense University. Madrid, Spain
  3. 3 Private practice. DDS. PhD. Madrid, Spain
  4. 4 Associate Professor. MD, PhD. Department of Human Anatomy and Embriology, School of Medicine. University of Alcalá, Alcalá de Henares, Madrid, Spain
  5. 5 Full Professor. MD. PhD. Department of Physiology. School of Medicine. Complutense University. Madrid, Spain
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Revista:
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Año de publicación: 2019

Volumen: 24

Número: 5

Páginas: 11

Tipo: Artículo

DOI: 10.4317/MEDORAL.22973 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Medicina oral, patología oral y cirugía bucal. Ed. inglesa

Resumen

The aim of this study was to assess the effect of local application of IGF-I on osseointegration of dental implants placed in osteoporotic bones. 16 rabbits were randomly distributed into two groups: eight animals were ovariectomized and fed a low-calcium diet for six weeks, in order to induce experimental osteoporosis, and the others were sham-operated and fed a standard diet. A titanium implant was inserted into the tibiae in both groups. In half of the rabbits, 4 μg of IGF-I was applied into the ostectomy, prior to the implant insertion. A total of 32 implants were placed. Animals were sacrificed two weeks after surgery and decalcified samples were processed for Bone-To-Implant Contact (BIC) and Bone Area Density (BAD) measurements. Analysis of variance (ANOVA) was used for statistical evaluation. P<0.05 was considered to be significant. Ovariectomy induced statistically significant lower BAD values (p=0.008) and a tendency towards lower BIC values when compared osteoporotic and healthy groups. The administration of 4 μg of IGF-I did not produce statistically significant differences neither on BIC nor on BAD values, neither in the osteoporotic animals nor in healthy. Within the limitations of this experimental study, local administration of 4 μg of IGF-I was not able to induce any changes in the osseointegration process two weeks after surgery, neither in healthy rabbits nor in the osteoporotic group.

Referencias bibliográficas

  • Fernández-Tresguerres Hernández-Gil, IF,Alobera Gracia, MA,del Canto Pingarrón, M,Blanco Jerez, L. (2006). Physiological bases of bone regeneration I. Histology and physiology of bone tissue. Med Oral Patol Oral Cir Bucal. 11. 47-51
  • Giustina, A,Mazziotti, G,Canalis, E. (2008). Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev. 29. 535-559
  • Gazzerro, E,Canalis, E. (2006). Skeletal actions of insulin-like growth factors. Expert Rev Endocrinol Metab. 1. 47-56
  • McCarthy, TL,Centrella, M,Canalis, E. (1989). Parathyroid Hormone Enhances the Transcript and Polypeptide Levels of Insulin-Like Growth Factor I in Osteoblast-Enriched Cultures from Fetal Rat Bone. Endocrinology. 124. 1247-1253
  • Canalis, E,McCarthy, TL,Centrella, M. (1989). Growth factors and the skeletal system. J Endocrinol Invest. 12. 577-584
  • Misra, M,Klibanski, A. (2006). Anorexia nervosa and osteoporosis. Rev Endocr Metab Disord. 7. 91-99
  • Grinspoon, S,Baum, H,Lee, K,Anderson, E,Herzog, D,Klibanski, A. (1996). Effects of short-term recombinant human insulin-like growth factor I administration on bone turnover in osteopenic women with anorexia nervosa. J Clin Endocrinol Metab. 81. 3864-3870
  • (2001). NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis: prevention, diagnosis and treatment. JAMA. 285. 785-795
  • Canalis, E. (2018). Management of endocrine disease: Novel anabolic treatments for osteoporosis. Eur J Endocrinol. 178. 33-44
  • Merheb, J,Temmerman, A,Rasmusson, L,Kübler, A,Thör, A,Quirynen, M. (2016). Influence of skeletal and local bone density on dental implant stability in patients with osteoporosis. Clin Impl Dent Rel Res. 18. 253-260
  • Zhang, M,Xuan, S,Bouxsein, ML,von Stechow, D,Akeno, N,Faugere, MC. (2002). Osteoblast-specific Knockout of the Insulin-like Growth Factor (IGF) Receptor Gene Reveals an Essential Role of IGF Signaling in Bone Matrix Mineralization. J Biol Chem. 277. 44005
  • Zhao, G,Monier-Faugere, MC,Langub, MC,Geng, Z,Nakayama, T,Pike, JW. (2000). Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation. Endocrinology. 141. 2674
  • Cemborain, A,Castilla Cortázar, I,García, M,Muguerza, B,Delgado, G,Díaz Sánchez, M. (2000). Effects of IGF-I treatment on osteopenia in rats with advanced liver cirrosis. Journal of Physiology and Biochemistry. 56. 919
  • Locatelli, V,Bianchi, VE. (2014). Effect of GH/IGF-1 on Bone Metabolism and Osteoporosis. Int J Endocrinol. 2014. 235060
  • Sugimoto, T,Nishiyama, K,Kuribayashi, F,Chiara, K. (1997). Serum Levels of Insulin-like Growth Factor (IGF) I, IGF-Binding Protein (IGFBP)-2, and IGFBP-3 in Osteoporotic Patients with and without Spinal Fractures. J Bone Miner Res. 12. 1272-1279
  • Garnero, P,Sornay-Rendu, E,Delmas, PD. (2000). Low serum IGF-I and occurrence of osteoporotic fractures in postmenopausal women. The Lancet. 355. 898-899
  • Langlois, JA,Rosen, CJ,Visser, M,Hannan, MT,Harris, T,Wilson, PW. (1998). Association between insulin-like growth factor I and bone mineral density in older women and men: the Framingham Heart Study. J Clin Endocrinol Metab. 83. 4257-4262
  • Backeljauw, PF,Underwood, LE. (1996). Prolonged treatment with recombinant insulin-like growth factor-I in children with growth hormone insensitivity syndrome. A clinical research center study. GHIS Collaborative Group. J Clin Endocrinol Metab. 81. 3312-3317
  • Carel, JC,Chaussain, JL,Chatelain, P,Savage, MO. (1996). Growth hormone insensitivity syndrome (Laron syndrome): main characteristics and effects of IGF-1 treatment. Diabetes Metab. 22. 251-256
  • Savage, MO,Dunger, DB. (1996). Recombinant IGF-I therapy in insulin-dependent diabetes mellitus. Diabetes Metab. 22. 257-260
  • Harvey, S,Hull, KL. (1997). Growth hormone. A paracrine growth factor? Endocrine. 7. 267-279
  • Tresguerres, IF,Clemente, C,Donado, M,Gómez-Pellico, L,Blanco, L,Alobera, MA. (2002). Local administration of growth hormone enhances periimplant bone reaction in an osteoporotic rabbit model: An histologic, histomorphometric and densitometric study. Clin Oral Impl Res. 13. 631-636
  • Martin Monge, E,Tresguerres, IF,Clemente, C,Tresguerres, AF. (2017). Local application of growth hormone to enhance osseointegration in osteoporotic bones: a morphometric and densitometric study. Int J Oral Maxillofac. 32. 751-758
  • Ke, HZ,Richards, WG,Li, X,Ominsky, MS. (2012). Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases. Endocr Rev. 33. 747-783
  • McClung, MR,Grauer, A,Boonen, S,Bolognese, MA,Brown, JP,Diez-Perez, A. (2014). Romosozumab in postmenopausal women with low bone mineral density. N Engl J Med. 370. 412-420
  • Anastasilakis, AD,Toulis, KA,Goulis, DG,Polyzos, SA,Delaroudis, S,Giomisi, A. (2009). Efficacy and safety of denosumab in postmenopausal women with osteopenia or osteoporosis: A systematic review and a meta-analysis. Horm Metab Res. 41. 721-729
  • Lindsay, RC,Mohan, S. (2016). Skeletal Effects of Growth Hormone and Insulin-like Growth Factor-I Therapy. Mol Cell Endocrinol. 5. 44-55
  • Martin Monge, E,Tresguerres, IF,Blanco, L,Khraisat, A,Rodriguez-Torres, R,Tresguerres, JAF. (2011). Validation of an Osteoporotic Animal Model for Dental Implant Analyses: An In Vivo Densitometric Study in Rabbits. Int J Oral Maxillofac Implants. 26. 725-730
  • Lugero, GG,Falco Caparbo V, de,Guzzo, ML,Konig B, Jr,Jorgetti, V. (2000). Histomorphometric evaluation of titanium in osteoporotic rabbits. Implant Dent. 9. 303-309
  • Duarte, PM,Cesar Neto, JB,Gonçalves, PF,Sallum, EA,Nociti, FH. (2003). Estrogen deficiency affects bone healing around titanium implants: a histometric study in rats. Implant Dent. 12. 340
  • De Melo, L,Piattelli, A,Lezzi, G,D'Avila, S,Zenóbio, EG,Shibli, JA. (2008). Human histologic evaluation of a six-year-old threaded implant retrieved from a subject with osteoporosis. J Contemp Dent Pract. 9. 99-105
  • Shibli, JA,Grande, PA,D'Avila, S,Iezzi, G,Piattelli, A. (2008). Evaluation of human bone around a dental implant retrieved from a subject with osteoporosis. Gen Dent. 56. 64
  • Rosen, CJ,Dimai, HP,Vereault, D,Donahue, LR,Beamer, WG,Farley, J. (1997). Circulating and Skeletal Insulin-like Growth Factor I (IGF-I) Concentrations in two inbred Strains of Mice with Different Bone Mineral Densities. Bone. 21. 217
  • Grinspoon, S,Thomas, L,Miller, K,Herzog, D,Klibanski, A. (2002). Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa. J Clin Endocrinol Metab. 87. 2883
  • Wang, Y,Nishida, S,Elalieh, HZ,Long, RK,Halloran, BP,Bikle, DD. (2006). Role of IGF-I signaling in regulating osteoclastogenesis. J Bone Miner Res. 21. 1350-1358
  • Lynch, SE,Buser, D,Hernandez, RA,Weber, HP,Stich, H,Fox, CH. (1991). Effects of the Platelet-Derived Growth Factor/Insulin-like Growth Factor-I Combination on Bone Regeneration Around Titanium Dental Implants. Results of a Pilot Study in Beagle Dogs. J Periodontol. 62. 710
  • Stefani, CM,Machado, MA,Sallum, EA,Salum, AW,Toledo, S,Nociti, H Jr. (2000). PlateletEderived growth factor/insuline like growth factor-1 combination and bone regeneration around implants placed into extraction sockets: a histometric study in dogs. Implant Dent. 9. 126
  • Nociti Junior, FH,Stefani, CM,Machado, MA,Sallum, EA,Toledo, S,Sallum, AW. (2000). Histometric evaluation of bone regeneration around immediate implants partially in contact with bone: a pilot study in dogs. Implant Dent. 9. 321
  • Xing, H,Wang, X,Xiao, S,Zhang, G,Li, M,Wang, P. (2017). Osseointegration of layer-by-layer polyelectrolyte multilayers loaded with IGF-1 and coated on titanium implant under osteoporotic condition. Int J Nanomedicine. 12. 7709-7720
  • Tresguerres, IF,Blanco, L,Clemente, C,Tresguerres, JA. (2003). Effects of local administration of growth hormone in peri-implant bone: an experimental study with implants in rabbit tibiae. Int J Oral Maxillofac Implants. 18. 807-811
  • Tresguerres, IF,Alobera, MA,Baca, R,Tresguerres, JA. (2005). Histologic, morphometric, and densitometric study of peri-implant bone in rabbits with local administration of growth hormone. Int J Oral Maxillofac Implants. 20. 193-202
  • Fowlkes, JL,Thrailkill, KM,Liu, L,Wahl, EC,Bunn, RC,Cockrell, GE. (2006). Effects of Systemic and Local Administration of Recombinant Human IGF-I (rhIGF-I) on De Novo Bone Formation in an Aged Mouse Model. J Bone Miner Res. 21. 1359-1366
  • Abbaspour, A,Takata, S,Matsui, Y,Katoh, S,Takahashi, M,Yasui, N. (2008). Continuous infusion of insulin-like growth factor-I into the epiphysis of the tibia. International Orthopaedics. 32. 395-402
Fuente de los datos: Dialnet