Effects of locally applied Insulin-like Growth Factor-I on osseointegration

  1. Juan López Quiles 1
  2. Alba Forteza-López 2
  3. Mónica Montiel 3
  4. Celia Clemente de Arriba 4
  5. Jesús A. Fernández-Tresguerres Hernández 5
  6. Isabel Fernández Tresguerres 1
  1. 1 Associate Professor. MD, PhD, DDS. Department of Dental Clinical Specialities, School of Dentistry, Complutense University. Madrid, Spain
  2. 2 Postgraduate student. DDS. Department of Dental Clinical Specialities, School of Dentistry, Complutense University. Madrid, Spain
  3. 3 Private practice. DDS. PhD. Madrid, Spain
  4. 4 Associate Professor. MD, PhD. Department of Human Anatomy and Embriology, School of Medicine. University of Alcalá, Alcalá de Henares, Madrid, Spain
  5. 5 Full Professor. MD. PhD. Department of Physiology. School of Medicine. Complutense University. Madrid, Spain
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Journal:
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Year of publication: 2019

Volume: 24

Issue: 5

Pages: 11

Type: Article

DOI: 10.4317/MEDORAL.22973 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Medicina oral, patología oral y cirugía bucal. Ed. inglesa

Abstract

The aim of this study was to assess the effect of local application of IGF-I on osseointegration of dental implants placed in osteoporotic bones. 16 rabbits were randomly distributed into two groups: eight animals were ovariectomized and fed a low-calcium diet for six weeks, in order to induce experimental osteoporosis, and the others were sham-operated and fed a standard diet. A titanium implant was inserted into the tibiae in both groups. In half of the rabbits, 4 μg of IGF-I was applied into the ostectomy, prior to the implant insertion. A total of 32 implants were placed. Animals were sacrificed two weeks after surgery and decalcified samples were processed for Bone-To-Implant Contact (BIC) and Bone Area Density (BAD) measurements. Analysis of variance (ANOVA) was used for statistical evaluation. P<0.05 was considered to be significant. Ovariectomy induced statistically significant lower BAD values (p=0.008) and a tendency towards lower BIC values when compared osteoporotic and healthy groups. The administration of 4 μg of IGF-I did not produce statistically significant differences neither on BIC nor on BAD values, neither in the osteoporotic animals nor in healthy. Within the limitations of this experimental study, local administration of 4 μg of IGF-I was not able to induce any changes in the osseointegration process two weeks after surgery, neither in healthy rabbits nor in the osteoporotic group.

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