Synthesis and conformational analysis of neoglycoconjugates derived from O- and S-glucose

  1. Rojas, V. 1
  2. Carreras, J. 1
  3. Corzana, F. 1
  4. Avenoza, A. 1
  5. Busto, J.H. 1
  6. Peregrina, J.M. 1
  1. 1 Universidad de La Rioja

    Universidad de La Rioja

    Logroño, España


Carbohydrate Research

ISSN: 0008-6215

Year of publication: 2013

Volume: 373

Pages: 1-8

Type: Article

DOI: 10.1016/J.CARRES.2013.02.013 PMID: 23545325 SCOPUS: 2-s2.0-84875403673 WoS: WOS:000319040400001 GOOGLE SCHOLAR

More publications in: Carbohydrate Research


Using olefin metathesis as a key step, four neoglycoconjugates incorporating α-. O-glucose, α-. S-glucose or β-. S-glucose as a carbohydrate unit and l-serine or l-cysteine as an amino acid moiety have been synthesized. The four-atom carbon spacer allows the carbohydrate to explore a wide-ranging conformational space, which may have important implications for the molecular recognition of these molecules. © 2013 Elsevier Ltd.