Cuando el Silicio transmuta en oro
- Francisco José Sánchez-Muniz 1
- María José González-Muñoz 2
- Adrián Macho-González 1
- Juana Benedí 3
- Alba Garcimartín 3
- Elvira López-Oliva 4
- Jorge A. Santos-López 3
- Sara Bastida 1
- 1 Departamento de Nutrición y Ciencia de los Alimentos. Facultad de Farmacia. Universidad Complutense de Madrid. España
- 2 Departamento de Ciencias Biomédicas, Unidad Docente de Toxicología, Facultad de Farmacia, Universidad de Alcalá, Madrid, Spain
- 3 Departamento de Farmacología, Farmacognosia y Botánica, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
- 4 Departamento de Fisiología, Facultad de Farmacia Universidad Complutense de Madrid, Madrid, Spain
ISSN: 2529-850X
Datum der Publikation: 2020
Ausgabe: 5
Nummer: 2
Seiten: 202-211
Art: Artikel
Andere Publikationen in: Journal of Negative and No Positive Results: JONNPR
Zusammenfassung
This article describes the virtues of a research focused on silicon, one of the most important but least known ingredients in beer, and its protective action at the neurodegenerative level. Among the various factors contributing to the Alzheimer's disease induction and development, aluminum, by concentrating in brain induces, among other mechanisms, pro-oxidant and inflammatory disorders. Silicon, by blocking these negative effects, becomes a star ingredient, which in alchemist terms suggests that has the property to transmute into gold.
Bibliographische Referenzen
- Sánchez-Muniz FJ, Bastida S. And still they say that fish is expensive [Y aún dicen que el pescado es caro]. JONNPR 2016; 1(7): 239-243.
- González-Muñoz MJ, Garcimartín A, Meseguer I, Mateos-Vega CJ, Orellana JM, Peña-Fernández A, Benedí J, Sánchez-Muniz FJ. Silicic acid and beer consumption reverses the metal imbalance and the prooxidant status induced by aluminum nitrate in mouse brain. J Alzheimer Dis 2017; 56(3): 917-927.
- Navarro Alarcón M, Gil Hernández F. Selenio, manganeso, cromo, molibdeno, yodo y otros oligoelementos minoritarios. En Gil A (ed.). Tratado de Nutrición. Bases fisiológicas y bioquímicas de la nutrición. Editorial Panamericana, Buenos Aires, 2017;pp. 545-575.
- Kirin Holding Company. Global beer consumption by country in 2016. 2017. Available online: www.kirinholdings.co.jp/english/news/2017/1221_01.html (accessed on 1 May 2019).
- Sánchez-Muniz FJ, Macho González A, Garcimartín A, Santos López JA, Benedi J, Bastida S, González-Muñoz MJ. The nutritional components of beer and its relationship with neurodegeneration and Alzheimer disease. Nutrients 2019; 11(7): pii E1558.
- De Keukeliere D, De Cooman L, Rong H, Heyerick A, Kalita J, Milligan SR. Functional properties of hop polyphenols. Basic Life Sci 199; 66: 739-760.
- Huang X, Wang J, Chen X, Liu P. Wang S, Song F, Ahang Z, Zhu F, Huang X, Liu J et al. The prenylflavonoid xanthohumol reduces Alzheimer-like changes and modulates multiple pathogenic molecular pathways in the neuro2a/APPswe cell model of AD. Front Pharmacol 2018; 9: 199.
- Alonso Aperte E, Varela Mosquera G. Ácido fólico y vitamina B12. En: Gil A. (ed.). Tratado de nutrición. Bases fisiológicas y bioquímicas de la nutrición. Vol 1. Panamericana, Buenos Aires, 2010, pp.525-546.
- Lorite Mingot D, Gesteiro E, Bastida S, Sánchez-Muniz FJ. Epigenetic effects of the pregnancy Mediterranean diet-adherence on the offspring metabolic syndrome markers. J Physiol Biochem 2017; 73(4): 495-510.
- Sánchez de Medina Contreras F. Metabolismo del alcohol y de otros componentes de los alimentos. En: Gil A. (ed.). Tratado de nutrición. Bases fisiológicas y bioquímicas de la nutrición. Vol 1. Panamericana, Buenos Aires, 2010, pp.735-747.
- Wang F, Zhang YJ, Zhou Y, Li Y, Zhou T, Zheng J, Zhang JJ, Li S, Zu DP, Li HB. Effects of beberages on alcohol metabolism: Potential health benefits and harmful impacts: Int J Mol Sci 2016; 17(3): 354.
- Gordillo Bastidas D, Gordillo Bastidas E. Metabolismo del alcohol. En Gordillo Bastidas D, Gordillo Bastidas E. (eds.). Nutrición molecular. McGraw Hill education, Mexico, 2015, pp. 179-188.
- Jurkić, Cepanec, Pavelić Pavelić K. Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid-releasing compounds: New perspectives for therapy. Nutr Metab (Lond). 2013; 10: 2.
- Peña A, Meseguer I, González-Muñoz MJ. Influencia del consumo moderado de cerveza sobre la toxicocinética del aluminio. Estudio agudo. Nutr Hosp 2007; 22: 371-376.
- Garcimartín A, Santos-Lopez JA, Bastida S, Benedí J, Sánchez-Muniz FJ. Silicon enriched restructures pork affects the lipoprotein profile, VLDL oxidation, and LDL receptor gene expression in aged rats fed an atherogenic diet. J Nutr 2015; 145(9):2039-2045.
- Santos-López JA, Garcimartín A, Merino P, López-Oliva ME, Bastida S, Benedí J, Sánchez-Muniz FJ. Effects of silicon vs. hydroxytyrosol-enriched restructured pork on liver oxidation status of aged rats fed high-saturated/high-cholesterol diet. PLoS One 2016; 11(1): e0147469.
- González-Muñoz MJ, Peña A, Meseguer MI. Role of beer as a possible protective factor in preventing Alzheimer’s disease. Food Chem Toxicol 2008; 46: 49-56.
- Merino P, Santos–López JA, Mateos C, Meseguer I, Garcimartin A, Bastida S, Sánchez-Muniz FJ, Benedí J, González-Muñoz MJ. Effects of nonalcoholic beer and its components silicon and hops in brain damage caused by aluminum intake. Food Chem Toxicol 2018; 118: 784-794.
- Granero S, Vicente M, Aguilar V, Martínez-Para MC, Domingo JL. Effects of beer as a source of dietary silicon on aluminium absorption and retention in mice. Trace Elem Electrol 2004; 21: 28–32.
- Exley, C. The aluminium-amyloid cascade hypothesis and Alzheimer’s disease. Subcell Biochem. 2005; 38: 225–234.
- Bolognin, S.; Messori, L.; Zatta, P. Metal ion physiopathology in neurodegenerative disorders. Neuromol Med 2009; 11: 223–238.
- Prince M, Ali GC, Guerchet M, Prina AM, Albanese E, Wu YT. Recent global trends in the prevalence and incidence of dementia, and survival with dementia. Alzheimers Res Ther 2016; 30: 23.
- World Health Organization (WHO). Risk Reduction of Cognitive Decline and Dementia: WHO Guidelines; WHO: Geneva, Switzerland.