Caracterización hemodinámica Doppler e inflamatoria de las preeclámpticasanálisis del efecto del tratamiento con parches de nitroglicerina

  1. Reyna Villasmil, Eduardo
Dirigée par:
  1. Mery Guerra Velásquez Directeur/trice
  2. Melchor Álvarez de Mon Soto Directeur

Université de défendre: Universidad de Alcalá

Fecha de defensa: 03 décembre 2012

Jury:
  1. José Antonio Girón González President
  2. José Barbarroja Escudero Secrétaire
  3. Luis Berlanga González Rapporteur
  4. María Kiriakidis Longhi Rapporteur
  5. M. Leticia Muñoz Zamarrón Rapporteur
Département:
  1. Medicina y Especialidades Médicas

Type: Thèses

Teseo: 342056 DIALNET lock_openTESEO editor

Résumé

Conclusions: Preeclamptic have significant higher values of Doppler velocimetry of uterine, umbilical, fetal renal and fetal hepatic artery and lower values of fetal cerebral middle artery than normotensive pregnant women. Patients with diagnosis of preeclampsia have higher values of interleukins, inflammation and endothelial dysfunction markers (excepting interleukin 10 and selectin L) than normotensive pregnant women. Nitroglycerin patches produced a significant reduction in pulsatility index, resistance index and systolic / diastolic ratio of uterine arteries, without producing significant changes in umbilical artery, fetal middle cerebral artery, fetal renal artery and hepatic renal artery. Treatment with nitroglycerin patches did no affect modifications in serum concentrations of inflammation and endothelial dysfunction markers. The use of nitroglycerin patches did not modify significantly neonatal variables, development of perinatal complications and mortality. However, there is a clinical reduction in the incidence of complications and perinatal mortality in treated preeclamptic patients. Nitroglycerin patches is associated with a higher frequency of headache.