Respuesta inmune innata y sus implicaciones fisiopatológicas

  1. Díaz Martín, D.
  2. Úbeda Cantera, M.
  3. López Suárez, A.
  4. Álvarez de Mon Soto, M.
Medicine: Programa de Formación Médica Continuada Acreditado

ISSN: 0304-5412

Year of publication: 2017

Series: 12

Issue: 24

Pages: 1388-1397

Type: Article


More publications in: Medicine: Programa de Formación Médica Continuada Acreditado


Abstract Overview Innate or natural immunity is the first line of defense against microorganisms. The term “innate” refers to the sensors involved in the pathogen recognition are encoded by genes in germline suffering non-somatic rearrangement to generate variants Components of the innate immunity The weapons of the innate immune system include molecular and cellular defense mechanisms that exist before an infection takes place, allowing them to respond to it quickly. Sensors of the innate immunity are specific structures common to groups of related pathogens, however they cannot distinguish subtle differences between them. Receptors of the innate immunity The first block analyzes receptors used by the innate immunity to identify characteristic molecules of groups of pathogens, as well as damaged and stressed cells, named pattern recognition receptors. Molecules of the innate immunity The second block examines in depth the soluble molecules that mediate innate immunity. These molecules act quickly against extracellular pathogens in three important ways: as opsonins, lytic agents and as pro-inflammatory agents.

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