Protocolo de manejo clínico de las metástasis óseas

  1. Villalobos León, M.L.
  2. Villalba Yllán, A.
  3. Álvarez-Mon Soto, M.
Journal:
Medicine: Programa de Formación Médica Continuada Acreditado

ISSN: 0304-5412

Year of publication: 2017

Issue Title: Enfermedades oncológicas (III) Tumores genitourinarios. Melanoma

Series: 12

Issue: 33

Pages: 1995-1999

Type: Article

DOI: 10.1016/J.MED.2017.04.024 DIALNET GOOGLE SCHOLAR

More publications in: Medicine: Programa de Formación Médica Continuada Acreditado

Abstract

Abstract Rational Bone metastases are a common manifestation of distant relapse from many types of solid cancers, especially those arising in the lung, breast, and prostate. Bone metastases represent a prominent source of morbidity. Skeletal-related events (SREs) due to bone metastases can include pain, pathologic fracture, hypercalcemia, and spinal cord compression. Treatment Across a wide variety of tumors involving bone, the frequency of SREs can be reduced through the use of osteoclast inhibitors, such as denosumab, or bisphosphonates. For most patients with a pathologic fracture of a long bone, this will necessitate surgical fixation. A significant proportion of patients with symptomatic skeletal metastases with inadequate pain relief can benefit from external beam radiation therapy (RT). Also minimally invasive methods for local ablation of skeletal metastases have been developed (image-guided radiofrequency ablation, cryoablation, focused ultrasound, and other percutaneous methods such as laser and microwave ablation and irreversible electroporation).

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Data source: Dialnet