Evaluación mediante ecografía doppler color del efecto de la combinación fija bimatoprost/timolol sobre el flujo sanguíneo ocular en pacientes con hipertensión ocularEstudio preliminar

  1. J. L. García-Pérez
  2. B. Puerto-Hernández
  3. G. Rebolleda Fernández
  4. F. J. Muñoz-Negrete
  5. C. González-Gordaliza
Journal:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Year of publication: 2010

Volume: 85

Issue: 4

Pages: 131-137

Type: Article

DOI: 10.1016/S0365-6691(10)70036-8 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Archivos de la Sociedad Española de Oftalmologia

Abstract

Purpose: To investigate the effects of topical bimatoprost (0.3 mg/ml)/timolol maleate (5 mg/ ml) fixed combination on retrobulbar blood flow in patients with ocular hypertension (OHT). Patients and methods: Twenty consecutive patients with OHT were prospectively randomised to either bimatoprost/timolol or placebo during a 12 weeks double masked treatment trial. Examinations were performed at baseline and after 12 weeks of treatment. Visual acuity, intraocular pressure (IOP), slit-lamp examination, automated static perimetry, systemic blood pressure and heart rate were all recorded. Retrobulbar blood flow measurements of the ophthalmic artery (AO) and central retinal artery (CRA) were measured by colour Doppler imaging. Results: IOP was significantly decreased by bimatoprost/timolol fixed combination (p < 0.0001). Bimatoprost/timolol fixed combination therapy resulted in a significant increase in end diastolic velocity (EDV) of the CRA (p = 0.03). In patients treated with bimatoprost/timolol a statistically significant correlation between IOP and EDV was observed after 12 weeks of treatment (r = -0.511, p = 0.045). The systolic (p = 0.54) and diastolic (p = 0.67) blood pressures and heart rate (p = 0.10) did not show statistically significant differences during the study period. Conclusions: Topical bimatoprost/timolol fixed combination significantly reduced IOP in patients with OHT. However, the only significant change observed in retrobulbar haemodynamics was an increase in EDV of the CRA, probably associated with a reduction in IOP.

Bibliographic References

  • Tranquart, F, Berges, O, Koskas, P, Arsene, S, Rossazza, C, Pisella, PJ. (2003). Color Doppler imaging of orbital vessels: personal experience and literature review. J Clin Ultrasound.. 315. 258
  • Flammer, J, Orgul, S, Costa, VP, Orzalesi, N, Krieglstein, GK, Serra, LM. (2002). The impact of ocular blood flow in glaucoma. Prog Retin Eye Res.. 214. 359
  • Kaiser, HJ, Schoetzau, A, Stumpfig, D. (1997). Blood-flow velocities of the extraocular vessels in patients with high-tension and normal-tension primary open-angle glaucoma. Am J Ophthalmol.. 123. 320
  • Nicolela, MT, Walman, BE, Buckley, AR. (1996). Ocular hypertension and primary open-angle glaucoma: a comparative study of their retrobulbar blood flow velocity. J Glaucoma. 5. 308
  • Yamazaki, Y, Drance, SM. (1997). The relationship between progression of visual field defects and retrobulbar circulation in patients with glaucoma. Am J Ophthalmol.. 1243. 287
  • Satilmis, M, Orgul, S, Doubler, B, Flammer, J. (2003). Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure. Am J Ophthalmol.. 1355. 664
  • Akarsu, C, Bilgili, MY. (2004). Color Doppler imaging in ocular hypertension and open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol.. 2422. 125
  • Cellini, M, Bernabini, B, Carbonelli, M, Zamparini, E, Campos, EC. (2007). Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension. Eye. 218. 1071
  • Baxter, GM, Williamson, TH. (1995). Color Doppler imaging of the eye: normal ranges, reproducibility, and observer variation. J Ultrasound Med.. 142. 91
  • Quaranta, L, Harris, A, Donato, F, Cassamali, M, Semeraro, F, Nascimbeni, G. (1997). Color Doppler imaging of ophthalmic artery blood flow velocity: a study of repeatability and agreement. Ophthalmology. 1044. 653
  • Matthiessen, ET, Zeitz, O, Richard, G, Klemm, M. (2004). Reproducibility of blood flow velocity measurements using colour decoded Doppler imaging. Eye. 18. 400
  • Harris, A, Williamson, TH, Martin, B, Shoemaker, JA, Sergott, RC, Spaeth, GL. (1995). Test/retest reproducibility of color Doppler imaging assessment of blood flow velocity in orbital vessels. J Glaucoma. 4. 281
  • Martínez, A, Sánchez, M. (2007). A comparison of the safety and intraocular pressure lowering of bimatoprost/timolol fixed combination versus latanoprost/timolol fixed combination in patients with open-angle glaucoma. Curr Med Res Opin.. 235. 1025
  • Martínez, A, Sánchez, M. (2008). Efficacy and safety of bimatoprost/ timolol fixed combination in the treatment of glaucoma or ocular hypertension. Expert Opin Pharmacother.. 91. 137
  • Hommer, A, Wickstrøm, J, Friis, MM, Steeds, C, Thygesen, J, Ferreras, A. (2008). A cost-effectiveness analysis of fixed-combination therapies in patients with open-angle glaucoma: an European perspective. Curr Med Res Opin.. 244. 1057
  • Brandt, JD, Cantor, LB, Katz, LJ, Batoosingh, AL, Chou, C, Bossowska, I. (2008). Bimatoprost/ timolol fixed combination: a 3-month double-masked, randomized parallel comparison to its individual components in patients with glaucoma or ocular hypertension. J Glaucoma. 173. 211
  • Harris, A, Spaeth, GL, Sergott, RC, Katz, LJ. (1995). Retrobulbar arterial hemodynamic effects of betaxolol and timolol in normal-tension glaucoma. Am J Ophthalmol.. 1202. 168
  • Evans, DW, Harris, A, Cantor, LB. (1999). Primary open-angle glaucoma patients characterized by ocular vasospasm demonstrate a different ocular vascular response to timolol versus betaxolol. J Ocul Pharmacol Ther.. 156. 479
  • Altan-Yaycioglu, R, Turker, G, Akdol, S, Acunas, G, Izgi, B. (2001). The effects of beta-blockers on ocular blood flow in patients with primary open angle glaucoma: a color Doppler imaging study. Eur J Ophthalmol.. 111. 37-46
  • Akarsu, C, Yilmaz, S, Taner, P, Ergin, A. (2004). Effect of bimatoprost on ocular circulation in patients with open-angle glaucoma or ocular hypertension. Graefes Arch Clin Exp Ophthalmol.. 242. 814
  • Koz, OG, Ozsoy, A, Yarangumeli, A, Kose, K, Kural, G. (2007). Comparison of the effects of travoprost, latanoprost and bimatoprost on ocular circulation: a 6-month clinical trial. Acta Ophthalmol Scand.. 85. 838
  • Alagoz, G, Gürel, K, Bayer, A, Serin, D, Celebi, S, Kukner, S. (2008). A comparative study of bimatoprost and travoprost: effect on intraocular pressure and ocular circulation in newly diagnosed glaucoma patients. Ophthalmologica. 2222. 88-95
  • Harris, A, Arend, O, Chung, HS, Kagemann, L, Cantor, L, Martin, B. (2000). A comparative study of betaxolol and dorzolamide effect on ocular circulation in normal tension glaucoma patients. Ophthalmology. 107. 430
  • Millar, JC, Wilson, WS, Carr, RD, Humphries, RG. (1995). Drug effects on intraocular pressure and vascular flow in the bovine perfused eye using radiolabelled microspheres. J Ocul Pharmacol Ther.. 111. 11-23
  • Steigerwalt, RD Jr, Laurora, G, Belcaro, GV, Cesarone, MR, De Sanctis, MT, Incandela, L. (2001). Ocular and retrobulbar blood flow in ocular hypertensives treated with topical timolol, betaxolol and carteolol. J Ocul Pharmacol Ther.. 176. 537
  • Bergstrand, IC, Heijl, A, Wollmer, P, Hansen, F, Harris, A. (2001). timolol increased retrobulbar flow velocities in untreated glaucoma eyes but not in ocular hypertension. Acta Ophthalmol Scand.. 795. 455
  • Ohkubo, H, Chiba, S. (1987). Vascular reactivities of simian ophthalmic and ciliary arteries. Curr Eye Res.. 610. 1197
  • Kimura, T, Yoshida, Y, Toda, N. (1992). Mechanisms of relaxation induced by prostaglandins in isolated canine uterine arteries. Am J Obstet Gynecol.. 1675. 1409
  • Allemann, R, Flammer, J, Haefliger, IO. (2003). Vasoactive properties of bimatoprost in isolated porcine ciliary arteries. Klin Monatsbl Augenheilkd.. 2203. 161
  • Martínez, A, Sánchez, M. Retrobulbar haemodynamic effects of the latanoprost/timolol and the dorzolamide/timolol fixed combinations in newly diagnosed glaucoma patients. Int J Clin Pract.. 61. 815
  • Harris, A, Joos, K, Kay, M, Evans, D, Shetty, R, Sponsel, WE. (1996). Acute IOP elevation with scleral suction: effects on retrobulbar haemodynamics. Br J Ophthalmol.. 80. 1055
  • Drance, SM, Crichton, A, Mills, RP. (1998). Comparison of the effect of latanoprost 0.005% and timolol 0.5% on the calculated ocular perfusion pressure in patients with normal-tension glaucoma. Am J Ophthalmol.. 1255. 585
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