Análisis morfométrico del endotelio de la córnea tras aplicación intraoperatoria de mitomicina C en la resección simple de pterigiónun estudio piloto

  1. J. Benítez-Herreros
  2. C. Pérez-Rico
  3. Mª Á. Montes-Mollón
  4. Y. Gómez-San-Gil
  5. M.Á. Teus-Guezala
Journal:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Year of publication: 2010

Volume: 85

Issue: 1

Pages: 11-15

Type: Article

DOI: 10.1016/S0365-6691(10)70003-4 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Archivos de la Sociedad Española de Oftalmologia

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Abstract

Purpose: To study the effects of mitomycin-C (MMC) on the corneal endothelium after pterygium surgery. Methods: Prospective, interventional, nonrandomized, observer-masked study. Twenty patients (20 eyes) with primary pterygium underwent surgery with pterygium simple excision followed by 0.02% MMC application for 1 minute. Preoperative, 10-day, 1-month and 3-month postoperative specular microscopy were performed. Mean cell density, coefficient of variation of mean cell area and percentage of hexagonal cells were measured. Results: Mean endothelial cell densities before and 3 months after surgery were 2,240.37 SD 347.92 cells/mm² (range: 1,020 to 2,703) and 2,283.86 SD 425.13 cells/mm² (range: 1,001 to 2,837), respectively. Mean coefficient of variation before and 3 months after surgery were 32.63 SD 4.65 (range: 22 to 48) and 33.00 SD 4.75 (range: 23 to 51), respectively. Mean percentage of hexagonal cells before and 3 months after surgery were 54.58 SD 6.60 (range: 46 to 71) and 55.26 SD 8.89 (range: 38 to 76), respectively. No statistically significant differences were found in any of the parameters studied when compared to the preoperative values. Conclusions: A single intraoperative application of 0.02% MMC for 1 minute during pterygium simple excision surgery does not seem to cause substantial changes in corneal endothelial cell density at 3 months.

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