Efecto de la mitomicina C en el engrosamiento corneal tras queratectomía subepitelial con láser excimer (LASEK)

  1. L. De Benito-Llopis
  2. M.A. Teus
  3. P. Drake-Casanova
Aldizkaria:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Argitalpen urtea: 2011

Alea: 86

Zenbakia: 7

Orrialdeak: 213-217

Mota: Artikulua

DOI: 10.1016/J.OFTAL.2011.02.006 DIALNET GOOGLE SCHOLAR lock_openSarbide irekia editor

Beste argitalpen batzuk: Archivos de la Sociedad Española de Oftalmologia

Laburpena

Purpose: To study the effect of mitomycin C (MMC) on the corneal regrowth after laser-assisted sub-epithelial keratectomy (LASEK). Methods: We performed a prospective, controlled, observer-masked study of 64 consecutive eyes scheduled to undergo LASEK to correct their myopia. The patients were divided into two age-matched groups, with group 1 including 32 eyes in which the ablation depth was < 50μm and received no MMC. Group 2 consisted of 32 eyes in which the ablation depth exceeded 50μm and were treated with intra-operative 0.02% MMC for 30seconds over the ablated zone. A masked observer measured the central corneal thickness (CCT) 1 and 3 months after surgery. We compared the change in CCT between both groups up to 3 months after surgery. Results: The mean patient age was 31.5 years (SD 4.6) and 31.6 (SD 8.7) years in groups 1 and 2, respectively (P=.9). Group 1 showed a mean CCT of 444.0 (SD 41.3) μm one month after surgery and 450.3 (SD 43.5) μm three months after surgery (P=.04). CCT in group 2 was 399.7 (SD 31.2) μm and 407.9 (SD 32.6) μm one and three months after surgery, respectively (P=.006). The difference in the CCT increases between both groups was not statistically significant (P=.6). Conclusions: A single intraoperative application of 0.02% MMC for 30seconds did not seem to cause a substantial change in the post-surgical corneal thickening expected after LASEK.

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