Efectos respiratorios del latanoprost en pacientes con enfermedad pulmonar obstructiva crónica (epoc)

  1. María Esther Arranz Marquez 1
  2. Miguel Ángel Teus Guezala 1
  3. F.Canseco González
  1. 1 Clínica Oftalmológica Novovisión,
    info

    Clínica Oftalmológica Novovisión,

    Madrid, España

Revue:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Année de publication: 2002

Volumen: 77

Número: 10

Pages: 553-558

Type: Article

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D'autres publications dans: Archivos de la Sociedad Española de Oftalmologia

Résumé

Purpose To study the respiratory effects of chronic therapy with latanoprost in Chronic Obstructive Pulmonary Disease (COPD) patients. Methods We prospectively performed a spirometry in 19 COPD patients treated with latanoprost for more than 3 months, and the same masked-examiner repeated the test, under the same conditions, one week after latanoprost wash-out. Results We found that latanoprost withdrawal increased forced espiratory volume (FEV1) (litre) from 1.5 S.D. 0.5 to 1.6 S.D. 0.5 and FEV1/FVC (forced vital capacity) index from 64.4 S.D. 8.6% to 66.5 S.D. 7.7% (both comparisons p=0.02, Wilcoxon signed-rank test). Conclusion Chronic therapy with latanoprost seems to induce a mild, though statistically significant, bronchoconstriction in COPD patients (Arch Soc Esp Oftalmol 2002; 77: 553-558). Key words

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