Más allá del ecocardiograma en el diagnóstico de la insuficiencia cardiaca
- Roel Conde, Ana 1
- Muñoz, Míriam Estébanez
- Hernández, Carmen Gonzalez 1
- Sánchez, David Martí
- 1 Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá de Henares
ISSN: 2530-2787
Year of publication: 2019
Volume: 4
Issue: 1
Pages: 15-19
Type: Article
More publications in: RIECS: Revista de Investigación y Educación en Ciencias de la Salud
Abstract
Amyloidosis is a systemic disease caused by the extracellularaccumulation of a misfolded protein in different tissues. Among the most frequent typesof amyloid,we find the transthyretin (ATTR) which is subdivided into two subtypes, the mutated ATTR that is hereditary and the wild-type ATTR. It is characterized by heterogeneous manifestations althoughthe cardiac involvementstands out as the main cause of mortality. Transthyretin cardiac amyloidosis isunderdiagnosed and requires a high clinical suspicion. We present a case of an 84-year-old patient admitted to Internal Medicine becauseof acuteheart failure. The echocardiogram and cardiac MRI show signs of restrictive cardiomyopathy secondary to amyloidosis that is confirmed with the histological study of subcutaneous fat and the type of amyloid is finally established by technetium-diphosphate scintigraphy. This entity requires specific management and has a prognosis that differs from other types of heart failure.