Protocolo diagnóstico y terapéutico del brote de esclerosis múltiple

  1. Delgado, F. Romero
  2. Margarit, B. Povedano
  3. Monteiro, G. Carvalho
  4. Izquierdo, A. Yusta
Journal:
Medicine: Programa de Formación Médica Continuada Acreditado

ISSN: 0304-5412

Year of publication: 2019

Issue Title: Enfermedades del sistema nervioso (IX)Enfermedades desmielinizantes del sistema nervioso central

Series: 12

Issue: 78

Pages: 4630-4633

Type: Article

DOI: 10.1016/J.MED.2019.05.014 DIALNET GOOGLE SCHOLAR

More publications in: Medicine: Programa de Formación Médica Continuada Acreditado

Abstract

Resumen La mayoría de las enfermedades desmielinizantes cursan con brotes y períodos de remisión. El diagnóstico del brote es clínico, entendiendo como tal la aparición de nuevos síntomas neurológicos o el empeoramiento de los existentes durante un período de tiempo superior a 24 horas, en ausencia de fiebre u otra condición que pudiera ocasionar un empeoramiento transitorio. Si estos producen discapacidad, deben ser tratados para acortar los tiempos de recuperación y mejorar la calidad de vida del paciente. El tratamiento habitualmente se realiza mediante bolos de megadosis de metilprednisolona; si no se obtiene respuesta, el tratamiento con plasmaféresis ha demostrado eficacia. Most demyelinating diseases progress with flare-ups and periods of remission. The diagnosis of a flare-up is clinical and is defined as the onset of new neurological symptoms or the worsening of existing symptoms for a period greater than 24h, in the absence of fever or other condition that could cause temporary worsening. If these flare-ups cause disability, they should be treated to shorten the recovery time and improve the patient's quality of life. The treatment is typically performed with a bolus megadose of methylprednisolone; if there is no response, treatment with plasmapheresis may be considered as it has been shown effective.

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