Evidencia científica sobre productos de tabaco calentado. Una revisión narrativa

Referencias bibliográficas

• Adriaens, K., Van Gucht, D., & Baeyens, F.(2018). IQOSTM vs. e-cigarette vs. tobacco cigarette: a direct comparison of short-term effects after overnight-abstinence. International Journal of Environmental Research and Public Health, 15(12), 2902.
• Auer, R., Concha-Lozano, N., Jacot-Sadowski, I., Cornuz, J., & Berthet, A. (2017).Heat-not-burn tobacco cigarettes: smoke by any other name. JAMA internal medicine, 177(7), 1050-1052.
• Bekki, K., Inaba, Y., Uchiyama, S., & Kunugita, N. (2017). Comparison of chemicals in mainstream smoke in heat-not-burn tobacco and combustion cigarettes. Journal of UOEH, 39(3), 201-207.
• Breheny, D., Adamson, J., Azzopardi, D.,Baxter, A., Bishop, E., Carr, T., ... & Lowe,F. (2017). A novel hybrid tobacco product that delivers a tobacco flavour note with vapour aerosol (part 2): in vitro biological assessment and comparison with different tobacco-heating products. Foodand Chemical Toxicology, 106, 533-546.
• Buratto, R., Correia, D., Parel, M., Crenna,M., Bilger, M., & Debrick, A. (2018).Determination of eight carbonyl compounds in aerosols trapped in phosphate buffer saline solutions to support in vitro assessment studies. Talanta, 184, 42-49.
• Caponnetto, P., Maglia, M., Prosperini, G.,Busà, B., & Polosa, R. (2018). Carbon monoxide levels after inhalation from new generation heated tobacco products. Respiratory research, 19(1), 1-4.
• Choukrallah, M. A., Sierro, N., Martin, F.,Baumer, K., Thomas, J., Ouadi, S., ... & Ivanov, N. V. (2019). Tobacco Heating System 2.2 has a limited impact on DNA methylation of candidate enhancers in mouse lung compared with cigarette smoke. Food and Chemical Toxicology,123, 501-510.
• Davis, B., Williams, M., & Talbot, P. (2019).iQOS: evidence of pyrolysis and reléase of a toxicant from plastic. Tobacco control,28(1), 34-41.
• Eaton, D., Jakaj, B., Forster, M., Nicol, J., Ma-vropoulou, E., Scott, K., ... & Proctor, C.J. (2018). Assessment of tobacco heating product THP1. 0. Part 2: Product design, operation and thermophysical characterisation. Regulatory Toxicology and Pharmacology, 93, 4-13.
• Eriksen, M. B., & Frandsen, T. F. (2018). Theimpact of patient, intervention, comparison, outcome (PICO) as a search strategy tool on literature search quality: asystematic review. Journal of the Medical Library Association: JMLA, 106(4), 420.
• Food and Drug Administration(FDA). (2020). FDA Authorizes Marketing of IQOS Tobacco Heating System with ‘Reduced Exposure’Information. Recuperado de: https://www.fda.gov/news-events/press-announcements/fda-authorizes-marketing-iqexposure-information#:~:text=The%20FDA%20previously%20authorized%20t h e , t o b a c c o % 2 0 a p p l i c a t i o n % 2 0(PMTA)%20pathway.&text=The%20I Q O S % 2 0 s y s t e m % 2 0 h e a t s % 2 0tobacco,harmful%20and%20potential-ly%20harmful%20chemicals
• Gale, N., McEwan, M., Eldridge, A. C.,Fearon, I. M., Sherwood, N., Bowen, E., ...& Wakenshaw, L. (2019). Changes in biomarkers of exposure on switching from a conventional cigarette to tobacco heating products: a randomized, controlled study in healthy Japanese subjects. Nicotine and Tobacco Research, 21(9), 1220-1227.
• Gasparyan, H., Mariner, D., Wright, C.,Nicol, J., Murphy, J., Liu, C., & Proctor,C. (2018). Accurate measurement of main aerosol constituents from heated tobacco products (HTPs): Implications for a fundamentally different aerosol. Regulatory Toxicology and Pharmacology,99, 131-141.
• Glantz S. A. (2018). Heated tobacco products: the example of IQOS. Tobacco control, 27(Suppl 1), s1–s6.
• Glantz, S. A. (2018). PMI’s own in vivo clinical data on biomarkers of potential harm in Americans show that IQOS is not detectably different from conventional cigarettes.Tobacco control, 27(Suppl 1), s9-s12.
• Gonzalez-Suarez, I., Martin, F., Marescotti, D.,Guedj, E., Acali, S., Johne, S., ... & Frentzel, S.(2016). In vitro systems toxicology assessment of a candidate modified risk tobacco product shows reduced toxicity compared to that of a conventional cigarette. Chemical research in toxicology, 29(1), 3-18.
• Grana, R., Benowitz, N., & Glantz, S. A.(2014). E-cigarettes: a scientific review.Circulation, 129(19), 1972–1986.
• Haswell, L. E., Corke, S., Verrastro, I., Bax-ter, A., Banerjee, A., Adamson, J., ... & Minet, E. (2018). In vitro RNA-seq-based toxicogenomics assessment shows reduced biological effect of tobacco heating products when compared to cigarette smoke. Scientific reports, 8(1), 1145.
• Haziza, C., de La Bourdonnaye, G., Donelli,A., Poux, V., Skiada, D., Weitkunat, R., ...& Lüdicke, F. (2019). Reduction in exposure to selected harmful and potentially harmful constituents approaching those observed upon smoking abstinence in smokers switching to the menthol tobacco heating system 2.2 for 3 months (Part 1).Nicotine and Tobacco Research, 5, 1–10.
• Haziza, C., de La Bourdonnaye, G., Merlet,S., Benzimra, M., Ancerewicz, J., Donelli,A., ... & Lüdicke, F. (2016). Assessment of the reduction in levels of exposure to harmful and potentially harmful constituents in Japanese subjects using a novel tobacco heating system compared with conventional cigarettes and smoking abstinence: A randomized controlled study in confinement. Regulatory Toxicology and Pharmacology, 81, 489-499.
• Haziza, C., de La Bourdonnaye, G., Skiada,D., Ancerewicz, J., Baker, G., Picavet, P., & Lüdicke, F. (2016). Evaluation of the Tobacco Heating System 2.2. Part 8: 5-Day randomized reduced exposure clinical study in Poland. Regulatory Toxicology and Pharmacology, 81, S139-S150.
• Iskandar, A. R., Mathis, C., Martin, F., Leroy,P., Sewer, A., Majeed, S., ... & Guedj,E. (2017). 3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product. ALTEX-Alternatives to animal experimentation,34(1), 23-48.
• Iskandar, A. R., Mathis, C., Schlage, W. K.,Frentzel, S., Leroy, P., Xiang, Y., ... & Guedj,E. (2017). A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures. Toxicology in vitro, 39, 29-51.
• Jaccard, G., Kondylis, A., Gunduz, I., Pijnenburg,J., & Belushkin, M. (2018). Investigation and comparison of the transfer of TSNA from tobacco to cigarette mainstream smoke and to the aerosol of a heated tobacco product, THS2. 2. Regulatory Toxicology andPharmacology, 97, 103-109.
• Jaunky, T., Adamson, J., Santopietro, S., Terry,A., Thorne, D., Breheny, D., ... & Gaça, M.(2018). Assessment of tobacco heating product THP1. 0. Part 5: in vitro dosimetric and cytotoxic assessment. RegulatoryToxicology and Pharmacology, 93, 52-61.
• Kogel, U., Titz, B., Schlage, W. K., Nury, C.,Martin, F., Oviedo, A., ... & Ivanov, N. V.(2016). Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated versión revealed reduced cellular and molecular exposure effects compared with men -tholated and non-mentholated cigarette smoke. Regulatory Toxicology and Pharmacology, 81 Suppl 2, S123-S138.
• Leigh, N. J., Palumbo, M. N., Marino, A.M., O’Connor, R. J., & Goniewicz, M. L.(2018). Tobacco-specific nitrosamines(TSNA) in heated tobacco product IQOS.Tobacco control, 27(Suppl 1), s37-s38.
• Leigh, N. J., Tran, P. L., O’Connor, R. J., &Goniewicz, M. L. (2018). Cytotoxic effects of heated tobacco products (HTP)on human bronchial epithelial cells. Tobacco control, 27(Suppl 1), s26-s29.
• Li, X., Luo, Y., Jiang, X., Zhang, H., Zhu, F.,Hu, S., ... & Pang, Y. (2019). Chemical analysis and simulated pyrolysis of tobacco heating system 2.2 compared to conventional cigarettes. Nicotine and Tobacco Research, 21(1), 111-118.
• Lo Sasso, G., Titz, B., Nury, C., Boué, S., Phil-lips, B., Belcastro, V., ... & Dulize, R. (2016).Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe−/−mice–a systems toxicology analysis. Inhalation Toxicology, 28(5), 226-240.
• Lüdicke, F., Ansari, S. M., Lama, N., Blanc,N., Bosilkovska, M., Donelli, A., ... & Weitkunat, R. (2019). Effects of switching to a Heat-Not-Burn tobacco producton biologically relevant biomarkers to assess a candidate modified risk tobacco product: a randomized trial. Cancer Epidemiology and Prevention Biomarkers, 28(11),1934-1943.
• Lüdicke, F., Picavet, P., Baker, G., Haziza,C., Poux, V., Lama, N., & Weitkunat, R.(2018). Effects of switching to the menthol tobacco heating system 2.2, smoking abstinence, or continued cigarette smoking on clinically relevant risk markers: arandomized, controlled, open-label, multicenter study in sequential confinement and ambulatory settings (Part 2). Nicotine and Tobacco Research, 20(2), 173-182.
• Malinska, D., Szymański, J., Patalas-Krawc-zyk, P., Michalska, B., Wojtala, A., Prill, M.,... & Johne, S. (2018). Assessment of mitochondrial function following short-andlong-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes. Foodand Chemical Toxicology, 115, 1-12.
• Martin, F., Talikka, M., Ivanov, N. V., Haziza,C., Hoeng, J., & Peitsch, M. C. (2016).Evaluation of the tobacco heating system2.2. Part 9: Application of systems pharmacology to identify exposure response markers in peripheral blood of smokers switching to THS2. 2. Regulatory Toxicology and Pharmacology, 81, S151-S157.
• McNeill, A., Brose, L. S., Calder, R., Bauld, L.,& Robson, D. (2018). Evidence review of e-cigarettes and heated tobacco products2018. A report commissioned by Public Health England. London: Public Health England.
• Munakata, S., Ishimori, K., Kitamura, N., Ishi-kawa, S., Takanami, Y., & Ito, S. (2018). Oxidative stress responses in human bronchial epithelial cells exposed to cigarette smoke and vapor from tobacco-and nicotine-containing products. Regulatory Toxicology and Pharmacology, 99, 122-128.
• Murphy, J., Liu, C., McAdam, K., Ga ҫa, M.,Prasad, K., Camacho, O., ... & Proctor, C.(2018). Assessment of tobacco heatingproduct THP1. 0. Part 9: the placement of a range of next-generation products on an emissions continuum relative to cigarettes via pre-clinical assessment studies. Regulatory Toxicology and Pharmacology, 93, 92-104.
• Nabavizadeh, P., Liu, J., Havel, C. M., Ibra-him, S., Derakhshandeh, R., Jacob Iii, P., & Springer, M. L. (2018). Vascular endothelial function is impaired by aerosol from a single IQOS Heat Stick to the same extent as by cigarette smoke. Tobacco control, 27(Suppl 1), s13-s19.
• Ogden, M. W., Marano, K. M., Jones, B. A.,Morgan, W. T., & Stiles, M. F. (2015).Switching from usual brand cigarettes to a tobacco-heating cigarette or snus: Part2. Biomarkers of exposure. Biomarkers,20(6-7), 391-403.
• Ogden, M. W., Marano, K. M., Jones, B. A.,Morgan, W. T., & Stiles, M. F. (2015). Switching from usual brand cigarettes to a tobacco-heating cigarette or snus: Part 3. Biomarkers of biological effect. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 20(6-7), 404–410.
• Oviedo, A., Lebrun, S., Kogel, U., Ho, J., Tan,W. T., Titz, B., ... & Rodrigo, G. (2018).Evaluation of the Tobacco Heating System2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology end-points demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke. Regulatory Toxicology and Pharmacology, 81, S93-S122.
• Phillips, B., Szostak, J., Titz, B., Schlage, W. K.,Guedj, E., Leroy, P., ... & Sewer, A. (2019).A six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, com-pared with conventional cigarettes. Foodand Chemical Toxicology, 126, 113-141.
• Phillips, B., Veljkovic, E., Boué, S., Schlage, W.K., Vuillaume, G., Martin, F., ... & Oviedo,A. (2016). An 8-month systems toxicology inhalation/cessation study in Apoe−/−mice to investigate cardiovascular and respiratory exposure effects of a candidate modified risk tobacco product, THS 2.2,compared with conventional cigarettes.Toxicological Sciences, 149(2), 411-432.
• Poussin, C., Laurent, A., Peitsch, M. C., Ho-eng, J., & De Leon, H. (2016). Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells.Toxicology, 339, 73-86.
• Pratte, P., Cosandey, S., & Goujon Gin -glinger, C. (2017). Investigation of solid particles in the mainstream aerosol of the Tobacco Heating System THS2. 2 andmainstream smoke of a 3R4F reference cigarette. Human & experimental toxicology, 36(11), 1115-1120.
• Schaller, J. P., Keller, D., Poget, L., Pratte,P., Kaelin, E., McHugh, D., ... & Yerly, M.(2016). Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical composition, genotoxicity, cytotoxicity, and physical properties of the aerosol. Regulatory Toxicology and Pharmacology, 81, S27-S47.
• Schaller, J. P., Pijnenburg, J. P., Ajithkumar, A.,& Tricker, A. R. (2016). Evaluation of theTobacco Heating System 2.2. Part 3: In -fluence of the tobacco blend on the formation of harmful and potentially harmful constituents of the Tobacco Heating System 2.2 aerosol. Regulatory Toxicology and Pharmacology, 81, S48-S58.
• Sewer, A., Kogel, U., Talikka, M., Wong, E.T., Martin, F., Xiang, Y., ... & Peitsch, M.C. (2016). Evaluation of the Tobacco Heating System 2.2 (THS2. 2). Part 5: mi-croRNA expression from a 90-day rat inhalation study indicates that exposure toTHS2. 2 aerosol causes reduced effects on lung tissue compared with cigarette smoke. Regulatory Toxicology and Pharmacology, 81, S82-S92.
• Sturla, S. J., Boobis, A. R., FitzGerald, R. E.,Hoeng, J., Kavlock, R. J., Schirmer, K.,Whelan, M., Wilks, M. F., & Peitsch, M.C. (2014). Systems toxicology: from basic research to risk assessment. Chemical research in toxicology, 27(3), 314–329.
• Szostak, J., Boué, S., Talikka, M., Guedj,E., Martin, F., Phillips, B., ... & Hoeng, J.(2017). Aerosol from Tobacco Heating System 2.2 has reduced impact on mouse heart gene expression compared with cigarette smoke. Food and Chemical Toxicology, 101, 157-167.
• Taylor, M., Thorne, D., Carr, T., Breheny,D., Walker, P., Proctor, C., & Gaça, M.(2018). Assessment of novel tobacco heating product THP1. 0. Part 6: a com-parative in vitro study using contemporary screening approaches. Regulatory Toxicology and Pharmacology, 93, 62-70.
• Titz, B., Boué, S., Phillips, B., Talikka, M., Vi-hervaara, T., Schneider, T., ... & Schlage, W.K. (2016). Effects of cigarette smoke, cessation, and switching to two heat-not-burn tobacco products on lung lipid metabolism in C57BL/6 and Apoe−/− Mice—an integrative systems toxicology analysis. Toxicological Sciences, 149(2), 441-457.
• U.S. Department of Health and Human Ser-vices. (2010). A report of the Surgeon General: How tobacco smoke causes disease: the biology and behavioral basis for smoking-attributable disease. En: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Centers for Chronic Disease Prevention and Health Promotion -Office on Smoking and Health.
• Van der Toorn, M., Frentzel, S., De Leon, H.,Goedertier, D., Peitsch, M. C., & Hoeng,J. (2015). Aerosol from a candidate modified risk tobacco product has reduced effects on chemotaxis and transendothelial migration compared to combustion of conventional cigarettes. Food and Chemical Toxicology, 86, 81-87.
• Van der Toorn, M., Sewer, A., Marescotti,D., Johne, S., Baumer, K., Bornand, D., ...& Pak, C. (2018). The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product. Toxicology in Vitro, 50, 95-108.
• Wang, J., Yang, H., Shi, H., Zhou, J., Bai, R.,Zhang, M., & Jin, T. (2017). Nitrate and nitrite promote formation of tobacco-specific nitrosamines via nitrogen oxides intermediates during postcured storage under warm temperature. Journal of Chemistry, 2017.
• Wertz, M. S., Kyriss, T., Paranjape, S., &Glantz, S. A. (2011). The toxic effects of cigarette additives. Philip Morris’ Project mix reconsidered: an analysis of documents released through litigation. PLoSMed, 8(12), e1001145.
• Wong, E. T., Kogel, U., Veljkovic, E., Martin,F., Xiang, Y., Boue, S., ... & Ivanov, N. V.(2016). Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke. Regulatory Toxicology and Pharmacology, 81 Suppl 2, S59-S81.
• World Health Organization. (2019). Global health observatory data: Prevalence of tobacco smoking. Recuperado de: https://www.who.int/gho/tobacco/use/en/
• Zanetti, F., Sewer, A., Mathis, C., Iskandar,A. R., Kostadinova, R., Schlage, W. K., ...& Martin, F. (2016). Systems toxicology assessment of the biological impact of a candidate modified risk tobacco product on human organotypic oral epitelial cultures. Chemical Research in Toxicology,29(8), 1252-1269.
• Zanetti, F., Titz, B., Sewer, A., Sasso, G. L.,Scotti, E., Schlage, W. K., ... & Keppler, B.R. (2017). Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study. Food and Chemical Toxicology, 101, 15-35.