Efecto de la adición de células madre mesenquimales adultas obtenidas de grasa a una sutura meniscal en zona blanca-blanca. Un estudio experimental en conejos
- Comellas Melero, Nerea
- Diaz Heredia, Jorge
ISSN: 1139-8264
Year of publication: 2008
Volume: 11
Issue: 3
Pages: 104-109
Type: Article
More publications in: Revista española de investigaciones quirúrgicas
Abstract
The use of mesenchimal stem cells derived form fat (MSC) can increase the success rate of meniscal suture. 105 MSC were placed in a longitudinal lesion at the avascular zone of the medial menisci of 12 rabbits that was sutured with a single stitch. The contralateral knee was used as control without MSC. The animals were sacrificed after 12 weeks and the menisci were examined. In the 12 menisci treated with MSC, partial healing was observed in three and complete healing in another three. In the 12 controls there was partial healing in one and no complete healings. Microscopical analysis identified well formed meniscal fibrocartilage in the healed zones.