AB0035 TWO DIFFERENT ABNORMAL BEHAVIORS IN CD4+T LYMPHOCYTES IN FIBROMYALGIA PATIENTS AND FIBROMYALGIA ASSOCIATED TO SJÖGREN’S SYNDROME

  1. Monserratsanz, J. 1
  2. Movasat, A. 2
  3. Sosa Reina, M. D. 1
  4. Gomez Lahoz, A. M. 1
  5. Bohórquez, C. 1
  6. Pérez Gómez, A. 2
  7. Ruiz, L. 2
  8. Cabezas Leon, M. J. 2
  9. Sánchez Atrio, A. 2
  10. Albarrán, F. 2
  11. Álvarez de Mon, M. 2
  1. 1 Universidad de Alcalá
    info

    Universidad de Alcalá

    Alcalá de Henares, España

    ROR https://ror.org/04pmn0e78

  2. 2 Hospital Universitario Príncipe de Asturias
    info

    Hospital Universitario Príncipe de Asturias

    Alcalá de Henares, España

    ROR https://ror.org/01az6dv73

Journal:
Annals of the Rheumatic Diseases

ISSN: 0003-4967,  1468-2060

Year of publication: 2020

Volume: 79

Issue: Suppl 1

Pages: 1320-1321

Type: Article

DOI: 10.1136/ANNRHEUMDIS-2020-EULAR.5524 GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Annals of the Rheumatic Diseases

Sustainable development goals

Abstract

Background: Primary fibromyalgia syndrome is a prevalent rheumatic condition characterized by widespread pain and whose etiopathogenesis is not well understood. Fibromyalgia can also be secondary to other rheumatic diseases like Sjogren’s syndrome; however, its relation to this disease is unknown. It has been suggested that the immune system is involved in their pathogenesis. The role of activation stages and cytokines profiles of CD4+T lymphocytes in fibromyalgia or fibromyalgia secondary to Sjogren´s syndrome are completely unclear and could play a key role in the pathophysiology of these diseases.Objectives: The objective of this study is to investigate the counts and distribution of the CD4+T lymphocyte activation subsets and their pattern of cytokine production in women with primary fibromyalgia, fibromyalgia secondary to Sjogren´s, Sjogren´s syndrome and healthy controls (HC). The counts and distribution of naïve (TN), central memory (TCM), effector memory (TEM) and effector (TE) CD4+T lymphocyte subsets were analyzed in these diseases. Furthermore, we investigated their pattern of IL-4, IL-10, IL-17A, IFNγ, and TNFα production.

Bibliographic References

  • [1] T helper 1 response is correlated with widespread pain, fatigue, sleeping disorders and the quality of life in patients with fibromyalgia.. Guggino G et al, Clin Exp Rheumatol. 2019.
  • [2] A Comparative Study of Fibromyalgia, Rheumatoid Arthritis, Spondyloarthritis, and Sjögren’s Syndrome. Bucourt E et al, Pain Med. 2019