Overexpression of insulin receptor substrate-4 is correlated with clinical staging in colorectal cancer patients

  1. Sanmartín-Salinas, Patricia
  2. Toledo-Lobo, M. Val
  3. Noguerales-Fraguas, Fernando
  4. Fernández-Contreras, María-Encarnación
  5. Guijarro, Luis G.
Journal of Molecular Histology

ISSN: 1567-2379 1567-2387

Year of publication: 2017

Volume: 49

Issue: 1

Pages: 39-49

Type: Article

DOI: 10.1007/S10735-017-9745-0 GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Journal of Molecular Histology

Sustainable development goals

Bibliographic References

  • Araki E, Lipes MA, Patti ME, Brüning JC, Haag B, Johnson RS, Kahn CR (1994) Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372:186–190. https://doi.org/10.1038/372186a0
  • Biasco G, Paganelli GM, Santucci R, Brandi G, Barbara L (1994) Methodological problems in the use of rectal cell proliferation as a biomarker of colorectal cancer risk. J Cell Biochem Suppl 19:55–60
  • Cai D, Dhe-Paganon S, Melendez PA, Lee J, Shoelson SE (2003) Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. J Biol Chem 278:25323–25330. https://doi.org/10.1074/jbc.M212430200
  • Cantarini MC, de la Monte SM, Pang M, Tong M, D’Errico A, Trevisani F, Wands JR (2006) Aspartyl-asparagyl beta hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms. Hepatology 44:446–457. https://doi.org/10.1002/hep.21272
  • Caunt CJ, Sale MJ, Smith PD, Cook SJ (2015) MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road. Nat Rev Cancer 15:577–592. https://doi.org/10.1038/nrc4000
  • Cuevas EP, Escribano O, Chiloeches A, Ramirez Rubio S, Román ID, Fernández-Moreno MD, Guijarro LG (2007) Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation. J Hepatol 46:1089–1098. https://doi.org/10.1016/j.jhep.2007.01.031
  • Cuevas EP et al (2009) RNAi-mediated silencing of insulin receptor substrate-4 enhances actinomycin D- and tumor necrosis factor-alpha-induced cell death in hepatocarcinoma cancer cell lines. J Cell Biochem 108:1292–1301. https://doi.org/10.1002/jcb.22359
  • Day E, Poulogiannis G, McCaughan F, Mulholland S, Arends MJ, Ibrahim AE, Dear PH (2013) IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer. Int J Exp Pathol 94:203–211. https://doi.org/10.1111/iep.12021
  • Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV (2007) Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2. Cell Cycle 6:705–713. https://doi.org/10.4161/cc.6.6.4035
  • Dlamini Z, Rupnarain C, Naicker S, Hull R, Mbita Z (2016) Expression analysis and association of RBBP6 with apoptosis in colon cancers. J Mol Histol 47:169–182. https://doi.org/10.1007/s10735-016-9663-6
  • Escribano O et al (2003) Insulin receptor substrate-4 signaling in quiescent rat hepatocytes and in regenerating rat liver. Hepatology 37:1461–1469. https://doi.org/10.1053/jhep.2003.50245
  • Esposito DL et al (2012) The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer. PLoS ONE 7:e36190. https://doi.org/10.1371/journal.pone.0036190
  • Fantin VR, Wang Q, Lienhard GE, Keller SR (2000) Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis. Am J Physiol Endocrinol Metab 278:E127–E133
  • Groulx JF, Khalfaoui T, Benoit YD, Bernatchez G, Carrier JC, Basora N, Beaulieu JF (2012) Autophagy is active in normal colon mucosa. Autophagy 8:893–902. https://doi.org/10.4161/auto.19738
  • Gual P, Le Marchand-Brustel Y, Tanti JF (2005) Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 87:99–109. https://doi.org/10.1016/j.biochi.2004.10.019
  • Hao L et al (2016) Expression and clinical significance of SALL4 and beta-catenin in colorectal cancer. J Mol Histol 47:117–128. https://doi.org/10.1007/s10735-016-9656-5
  • Hoxhaj G, Dissanayake K, MacKintosh C (2013) Effect of IRS4 levels on PI 3-kinase signalling. PLoS ONE 8:e73327. https://doi.org/10.1371/journal.pone.0073327
  • Ikink GJ, Boer M, Bakker ER, Hilkens J (2016) IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivation. Nat Commun 7:13567. https://doi.org/10.1038/ncomms13567
  • Jackson JG, Zhang X, Yoneda T, Yee D (2001) Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines. Oncogene 20:7318–7325. https://doi.org/10.1038/sj.onc.1204920
  • Karrman K et al (2009) The t(X;7)(q22;q34) in paediatric T-cell acute lymphoblastic leukaemia results in overexpression of the insulin receptor substrate 4 gene through illegitimate recombination with the T-cell receptor beta locus. Br J Haematol 144:546–551. https://doi.org/10.1111/j.1365-2141.2008.07453.x
  • Lebrun P, Baron V, Hauck CR, Schlaepfer DD, Van Obberghen E (2000) Cell adhesion and focal adhesion kinase regulate insulin receptor substrate-1 expression. J Biol Chem 275:38371–38377. https://doi.org/10.1074/jbc.M006162200
  • Liu SC, Wang Q, Lienhard GE, Keller SR (1999) Insulin receptor substrate 3 is not essential for growth or glucose homeostasis. J Biol Chem 274:18093–18099
  • Mehine M et al (2016) Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers. Proc Natl Acad Sci USA 113:1315–1320. https://doi.org/10.1073/pnas.1518752113
  • Mertens F et al (2011) The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4. Int J Cancer 128:487–491. https://doi.org/10.1002/ijc.25353
  • Miki H et al (2001) Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation. Mol Cell Biol 21:2521–2532. https://doi.org/10.1128/MCB.21.7.2521-2532.2001
  • Neutra M, Leblond CP (1966) Synthesis of the carbohydrate of mucus in the golgi complex as shown by electron microscope radioautography of goblet cells from rats injected with glucose-H3. J Cell Biol 30:119–136
  • Remmele W, Schicketanz KH (1993) Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer: computer-assisted image analysis (QIC score) vs. subjective grading (IRS). Pathol Res Pract 189:862–866. https://doi.org/10.1016/S0344-0338(11)81095-2
  • Román ID et al (2017) Infliximab therapy reverses the increase of allograft inflammatory factor-1 in serum and colonic mucosa of rats with inflammatory bowel disease. Biomarkers 22:133–144. https://doi.org/10.1080/1354750X.2016.1252950
  • Ruifrok AC, Johnston DA (2001) Quantification of histochemical staining by color deconvolution. Anal Quant Cytol Histol 23:291–299
  • Shanmugathasan M, Jothy S (2000) Apoptosis, anoikis and their relevance to the pathobiology of colon cancer. Pathol Int 50:273–279
  • Siegel R, Desantis C, Jemal A (2014) Colorectal cancer statistics, 2014. CA Cancer J Clin 64:104–117. https://doi.org/10.3322/caac.21220
  • Thorpe LM, Yuzugullu H, Zhao JJ (2015) PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. Nat Rev Cancer 15:7–24. https://doi.org/10.1038/nrc3860
  • Tseng YH, Ueki K, Kriauciunas KM, Kahn CR (2002) Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin. J Biol Chem 277:31601–31611. https://doi.org/10.1074/jbc.M202932200
  • Veronese N et al (2016) Prognostic impact and implications of extracapsular lymph node involvement in colorectal cancer: a systematic review with meta-analysis. Ann Oncol 27:42–48. https://doi.org/10.1093/annonc/mdv494
  • Weischenfeldt J et al (2017) Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking. Nat Genet 49:65–74. https://doi.org/10.1038/ng.3722
  • Withers DJ et al (1998) Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391:900–904. https://doi.org/10.1038/36116
  • Wu A, Chen J, Baserga R (2008) Nuclear insulin receptor substrate-1 activates promoters of cell cycle progression genes. Oncogene 27:397–403. https://doi.org/10.1038/sj.onc.1210636
  • Wu S, Zhou B, Xu L, Sun H (2009) IRS-2, but not IRS-1, can sustain proliferation and rescue UBF stabilization in InR or InR defective signaling of 32D myeloid cells. Cell Cycle 8:3218–3226. https://doi.org/10.4161/cc.8.19.9759
  • Wu S, Zhou B, Xu L, Sun H (2010) Interaction between nuclear insulin receptor substrate-2 and NF-κB in IGF-1 induces response in breast cancer cells. Oncol Rep 24:1541–1550