Apuntes históricos sobre el descubrimiento de los fármacos autorizados en el tratamiento del Trastorno Bipolar (TB)
- Francisco López-Muñoz 1
- Cecilio Álamo 2
- Cristina Zaragozá-Arnaez 2
- 1 Universidad Camilo José Cela, Madrid; Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid
- 2 Universidad de Alcalá, Madrid
ISSN: 1698-4277
Year of publication: 2023
Volume: 21
Issue: 3
Pages: 200-212
Type: Article
More publications in: Actualidad en farmacología y terapéutica
Abstract
In this paper, the authors review the history of the pharmacological treatment of bipolar disorder, from the first nonspecific sedative agents introduced in the 19th and early 20th century, such as solanaceae alkaloids, bromides and barbiturates, to John Cade’s experiments with lithium and the beginning of the so-called “Psychopharmacological Revolution” in the 1950s. We also describe the clinical studies and development processes, enabling the therapeutic introduction of pharmacological agents currently available for the treatment of bipolar disorder in its different phases and manifestations: lithium salts, valproic acid, carbamazepine, new antiepileptic drugs, basically lamotrigine, and atypical antipsychotic agents.