Arenavirusantecedentes, genética reversa, patogenia y dianas terapéuticas
- Víctor García Rodríguez
- Marta Pérez de Aguado
- Laura Pérez Martín
- Miriam Vela Domínguez
- M. Isabel Gegúndez Cámara dir.
- Cuadros González, Juan (dir.)
- Gegúndez Cámara, María Isabel (dir.)
- Florido Calleja, María Jesús (ed. lit.)
- Consuelo Giménez Pardo (dir.)
- María Rosario González Palacios (dir.)
- Lourdes Lledó García (dir.)
- Juan Romanyk (dir.)
- José Vicente Saz Pérez (dir.)
Argitaletxea: Editorial Universidad de Alcalá ; Universidad de Alcalá
ISBN: 9788416599493
Argitalpen urtea: 2017
Orrialdeak: 69-84
Mota: Liburuko kapitulua
Laburpena
Arenaviridae is a family consisting of a series of single-stranded ambisense RNA. Formerly classified into Old World (OW) and New World (NW) Arenavirus, S- segment based genomics hints at a common ancestor, not yet utterly clarified. Some are a cause of hemorrhagic fever, such as Lassa virus (LFV/LASV), the paradigm of this issue. LFV is mainly distributed along West Africa, being its natural host the rodent Mastomys natalensis. LFV binds to aestroglycan, a molecule present on the cell surface and which binds to proteins of the extracellular matrix itself, bringing about an immune response ¾not effective, not with standing, owing to its immunosuppressant condition¾. Dendritic cells (DC) are the first and far more affected cells. Manifestations fluctuate from general signs and symptomps to death (50% mortality in epidemies and up to 90% as to vertical transmission). Treatment based on ribavirin is useful, yet it has its limitations and furthermore, no vaccines have proven to be entirely successful.