Revisión del estado actual en la investigación sobre virus oncolíticos
- Beatriz Canchal Martínez
- Joaquín González García
- Alba Martínez Moreno
- Alejandro Mendieta Baro
- Lourdes Lledó García dir.
- Cuadros González, Juan (dir.)
- Gegúndez Cámara, María Isabel (dir.)
- Florido Calleja, María Jesús (ed. lit.)
- Consuelo Giménez Pardo (dir.)
- María Rosario González Palacios (dir.)
- Lourdes Lledó García (dir.)
- Juan Romanyk (dir.)
- José Vicente Saz Pérez (dir.)
Editorial: Editorial Universidad de Alcalá ; Universidad de Alcalá
ISBN: 9788416599493
Any de publicació: 2017
Pàgines: 87-100
Tipus: Capítol de llibre
Resum
An increasing number of viruses are being investigated for being used as a therapy against certain types of cancers. To study in this field, we first focus on gathering all the information about the mechanisms of action and the most interesting characteristics of the main oncolytic viruses. Thus, we discuss the role of the immune system because it is the most important aspect for a curative outcome; as being an obstacle to fully exploit this type of therapy. Therefore, we question the efficacy, selectivity and safety of oncolytic viruses based on the results of previous studies. These studies are mostly in premature stages, so we conclude that more research is required to complete all the knowledge about this issue, also highlighting the newest research fields such as armed viruses or carrier stem cells.