Epidemiología, patogenia, aspectos clínicos y últimos avances experimentales sobre la fiebre hemorrágica del Ébola
- Aparicio Minguijón, E. 1
- Pedregosa Barbas, J. 1
- Vicente Hernández, C. 1
- María Isabel Gegúndez Cámara dir. 1
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1
Universidad de Alcalá
info
- Cuadros González, Juan (coord.)
- María Isabel Gegúndez Cámara (coord.)
- Consuelo Giménez Pardo (coord.)
- Rosario González Palacios (coord.)
- Lourdes Lledó García (coord.)
- Juan Romanyk Cabrera (coord.)
- José Vicente Saz Pérez (coord.)
Editorial: Líneas de Distribución Logística del Papel
ISBN: 978-84-942694-0-0
Año de publicación: 2014
Páginas: 43-52
Tipo: Capítulo de Libro
Objetivos de desarrollo sostenible
Resumen
Ebolavirus and Marburgvirus are members of Filoviridae virus family that cause hemorrhagic fevers. Several epidemics have been described with high fatality rates, circumscribed to Africa, and there is high risk of importing into other continents. They have a wide variety of pathogenic mechanisms: avoiding host immune response, causing damages by invasion of numerous cell types and inducing a systemic inflammatory response. The infection presents nonspecific respiratory and digestive symptoms, internal bleeding which is evident in all mucous and mental disorders. Serology is the most appropriate diagnostic method. There is no effective treatment, thus only supportive measures can be applied. Currently, isolation is the only efficient mean of prevention. Possible treatments based on interferon, coagulation factors, and monoclonal antibodies, as well as vaccines, like the developed from vesicular stomatitis virus, are being investigated.