Publicaciones en colaboración con investigadores/as de Centro de Investigaciones Biológicas (15)

2024

  1. Flexible structural arrangement and DNA-binding properties of protein p6 from Bacillus subtillis phage ϕ29

    Nucleic Acids Research, Vol. 52, Núm. 4, pp. 2045-2065

2023

  1. Alternative Approaches to Understand Microtubule Cap Morphology and Function

    ACS Omega, Vol. 8, Núm. 4, pp. 3540-3550

  2. Chemical modulation of microtubule structure through the laulimalide/peloruside site

    Structure, Vol. 31, Núm. 1, pp. 88-99.e5

  3. Modulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency

    European Journal of Medicinal Chemistry, Vol. 259

  4. Structural insight into the stabilization of microtubules by taxanes

    eLife, Vol. 12

2018

  1. Engineering Erg10 Thiolase from Saccharomyces cerevisiae as a Synthetic Toolkit for the Production of Branched-Chain Alcohols

    Biochemistry, Vol. 57, Núm. 8, pp. 1338-1348

  2. High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design

    Scientific Reports, Vol. 8, Núm. 1

2016

  1. Molecular interactions and implications of aldose reductase inhibition by pga1 and clinically used prostaglandins

    Molecular Pharmacology, Vol. 89, Núm. 1, pp. 42-52

  2. Structural determinants of the dictyostatin chemotype for tubulin binding affinity and antitumor activity against taxane- And epothilone-resistant cancer cells

    ACS Omega, Vol. 1, Núm. 6, pp. 1192-1204

2015

  1. Restoration of Microtubule Interaction and Cytotoxicity in D-seco Taxanes upon Incorporation of 20-Hydroxymethyl-4-allyloxy Groups

    Organic Letters, Vol. 17, Núm. 24, pp. 6098-6101

2014

  1. Molecular recognition of epothilones by microtubules and tubulin dimers revealed by biochemical and NMR approaches

    ACS Chemical Biology, Vol. 9, Núm. 4, pp. 1033-1043

2013

  1. A structure-based design of new C2- and C13-substituted taxanes: Tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis

    Organic and Biomolecular Chemistry, Vol. 11, Núm. 18, pp. 3046-3056

2012

  1. Comparative Binding Energy (COMBINE) Analysis Supports a Proposal for the Binding Mode of Epothilones to β-Tubulin

    ChemMedChem, Vol. 7, Núm. 5, pp. 836-843

2011

  1. Identification of Aldo-Keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A1: Implications for antitumoral activity

    Cancer Research, Vol. 71, Núm. 12, pp. 4161-4171

2008

  1. Optimization of Taxane Binding to Microtubules: Binding Affinity Dissection and Incremental Construction of a High-Affinity Analog of Paclitaxel

    Chemistry and Biology, Vol. 15, Núm. 6, pp. 573-585