Publicaciones en colaboración con investigadores/as de Karolinska Institute (5)

2012

  1. Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway

    Journal of Biological Chemistry, Vol. 287, Núm. 36, pp. 30444-30454

2011

  1. Synthesis, modeling and evaluation of 3′-(1-aryl-1H-tetrazol-5- ylamino)-substituted 3′-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors

    Organic and Biomolecular Chemistry, Vol. 9, Núm. 3, pp. 892-901

2010

  1. 3′-[4-Aryl-(1,2,3-triazol-1-yl)]-3′-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase

    Journal of Medicinal Chemistry, Vol. 53, Núm. 7, pp. 2902-2912

2006

  1. N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors

    Journal of Medicinal Chemistry, Vol. 49, Núm. 26, pp. 7766-7773

2003

  1. Improving the selectivity of acyclic nucleoside analogues as inhibitors of human mitochondrial thymidine kinase: Replacement of a triphenylmethoxy moiety with substituted amines and carboxamides

    Bioorganic and Medicinal Chemistry Letters, Vol. 13, Núm. 18, pp. 3027-3030