Isabel
Iriepa Canalda
Profesor/a Titular Universidad
Universidad Complutense de Madrid
Madrid, EspañaPublicaciones en colaboración con investigadores/as de Universidad Complutense de Madrid (18)
2023
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Straightforward Synthesis of Bis[(trifluoromethyl)sulfonyl]ethylated Isocoumarins from 2-Ethynylbenzoates
Journal of Organic Chemistry, Vol. 88, Núm. 11, pp. 7373-7380
2020
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Homo-tris-nitrones derived from α-phenyl-n-tert-butylnitrone: Synthesis, neuroprotection and antioxidant properties
International Journal of Molecular Sciences, Vol. 21, Núm. 21, pp. 1-18
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Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models
Scientific Reports, Vol. 10, Núm. 1
2019
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Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 34, Núm. 1, pp. 479-489
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Quinoxalinetacrine QT78, a cholinesterase inhibitor as a potential ligand for Alzheimer’s disease therapy
Molecules, Vol. 24, Núm. 8
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Synthesis, neuroprotective and antioxidant capacity of PBN-related indanonitrones
Bioorganic Chemistry, Vol. 86, pp. 445-451
2018
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Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 155, pp. 839-846
2017
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5-Methyl-: N -(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5 H -indolo[2,3- b] quinolin-11-amine: A highly potent human cholinesterase inhibitor
MedChemComm, Vol. 8, Núm. 6, pp. 1307-1317
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Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases
Angewandte Chemie - International Edition, Vol. 56, Núm. 41, pp. 12765-12769
2016
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Potent anticholinesterasic and neuroprotective pyranotacrines as inhibitors of beta-amyloid aggregation, oxidative stress and tau-phosphorylation for Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 118, pp. 178-192
2015
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Pyranopyrazolotacrines as nonneurotoxic, Aβ-anti-aggregating and neuroprotective agents for Alzheimer's disease
Future Medicinal Chemistry, Vol. 7, Núm. 7, pp. 845-855
2014
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Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 80, pp. 543-561
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Structural basis of drugs that increase cardiac inward rectifier Kir2.1 currents
Cardiovascular Research, Vol. 104, Núm. 2, pp. 337-346
2013
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Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore
Biochemical Pharmacology, Vol. 86, Núm. 2, pp. 267-278
2012
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Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease
European Journal of Medicinal Chemistry, Vol. 54, pp. 750-763
2006
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Nitric oxide blocks hKv1.5 channels by S-nitrosylation and by a cyclic GMP-dependent mechanism
Cardiovascular Research, Vol. 72, Núm. 1, pp. 80-89
2005
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Synthesis, structural and conformational study of selected N-substituted phthalimides
Central European Journal of Chemistry, Vol. 3, Núm. 4, pp. 683-704
2003
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Effects of irbesartan on cloned potassium channels involved in human cardiac repolarization
Journal of Pharmacology and Experimental Therapeutics, Vol. 304, Núm. 2, pp. 862-873