Publicaciones en colaboración con investigadores/as de Instituto de Química Física Rocasolano (12)

2022

  1. Identification of 1,2,3-triazolium salt-based inhibitors of Leishmania infantum trypanothione disulfide reductase with enhanced antileishmanial potency in cellulo and increased selectivity

    European Journal of Medicinal Chemistry, Vol. 244

  2. The inhibition of NCS-1 binding to Ric8a rescues fragile X syndrome mice model phenotypes

    Frontiers in Neuroscience, Vol. 16

2021

  1. Mitochondria selective trackers for long-term imaging based on readily accessible neutral BODIPYs

    Chemical Communications, Vol. 57, Núm. 43, pp. 5318-5321

2019

  1. Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

    Nature Communications, Vol. 10, Núm. 1

  2. Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase

    ACS Infectious Diseases, Vol. 5, Núm. 6, pp. 873-891

2018

  1. Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators

    Journal of Medicinal Chemistry, Vol. 61, Núm. 14, pp. 5910-5921

  2. Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability

    European Journal of Medicinal Chemistry, Vol. 149, pp. 238-247

2017

  1. Interference of the complex between NCS-1 & Ric8a with phenothiazines regulates synaptic function & is an approach for fragile X syndrome

    Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Núm. 6, pp. E999-E1008

  2. Structure-based domain assignment in Leishmania infantum EndoG: Characterization of a pH-dependent regulatory switch and a C-Terminal extension that largely dictates DNA substrate preferences

    Nucleic Acids Research, Vol. 45, Núm. 15, pp. 9030-9045

2015

  1. Comparison of hydrocarbon-and lactam-bridged cyclic peptides as dimerization inhibitors of Leishmania infantum trypanothione reductase

    RSC Advances, Vol. 5, Núm. 69, pp. 55784-55794

2014

  1. Frq2 from Drosophila melanogaster: Cloning, expression, purification, crystallization and preliminary X-ray analysis

    Acta Crystallographica Section F:Structural Biology Communications, Vol. 70, Núm. 4, pp. 530-534

  2. The guanine-exchange factor Ric8a binds to the Ca2+ sensor NCS-1 to regulate synapse number and neurotransmitter release

    Journal of Cell Science, Vol. 127, Núm. 19, pp. 4246-4259