Publicaciones en colaboración con investigadores/as de Instituto de Química Médica (15)

2022

  1. Identification of 1,2,3-triazolium salt-based inhibitors of Leishmania infantum trypanothione disulfide reductase with enhanced antileishmanial potency in cellulo and increased selectivity

    European Journal of Medicinal Chemistry, Vol. 244

  2. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library

    European Journal of Medicinal Chemistry, Vol. 243

2021

  1. Efficient Dimerization Disruption of Leishmania infantum Trypanothione Reductase by Triazole-phenyl-thiazoles

    Journal of Medicinal Chemistry, Vol. 64, Núm. 9, pp. 6137-6160

  2. Small molecule–peptide conjugates as dimerization inhibitors of leishmania infantum trypanothione disulfide reductase

    Pharmaceuticals, Vol. 14, Núm. 7

2020

  1. Pseudoirreversible slow-binding inhibition of trypanothione reductase by a protein–protein interaction disruptor

    British Journal of Pharmacology, Vol. 177, Núm. 22, pp. 5163-5176

2019

  1. Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase

    ACS Infectious Diseases, Vol. 5, Núm. 6, pp. 873-891

2018

  1. Identification of a novel 2-oxindole fluorinated derivative as in vivo antitumor agent for prostate cancer acting via AMPK activation

    Scientific Reports, Vol. 8, Núm. 1

  2. Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability

    European Journal of Medicinal Chemistry, Vol. 149, pp. 238-247

2017

  1. First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity#

    European Journal of Medicinal Chemistry, Vol. 135, pp. 49-59

  2. Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides

    European Journal of Medicinal Chemistry, Vol. 140, pp. 615-623

  3. Interference of the complex between NCS-1 & Ric8a with phenothiazines regulates synaptic function & is an approach for fragile X syndrome

    Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Núm. 6, pp. E999-E1008

2015

  1. Comparison of hydrocarbon-and lactam-bridged cyclic peptides as dimerization inhibitors of Leishmania infantum trypanothione reductase

    RSC Advances, Vol. 5, Núm. 69, pp. 55784-55794

2013

  1. 5′-trityl-substituted thymidine derivatives as a novel class of antileishmanial agents: Leishmania infantum EndoG as a potential target

    ChemMedChem, Vol. 8, Núm. 7, pp. 1161-1174

  2. Probing the Dimerization Interface of Leishmania infantum Trypanothione Reductase with Site-Directed Mutagenesis and Short Peptides

    ChemBioChem, Vol. 14, Núm. 10, pp. 1212-1217

  3. Synthetic cannabinoid quinones: Preparation, in vitro antiproliferative effects and in vivo prostate antitumor activity

    European Journal of Medicinal Chemistry, Vol. 70, pp. 111-119