Publicacións nas que colabora con Ana Negri Martinez (19)

2013

  1. Probing the Dimerization Interface of Leishmania infantum Trypanothione Reductase with Site-Directed Mutagenesis and Short Peptides

    ChemBioChem, Vol. 14, Núm. 10, pp. 1212-1217

2012

  1. Erratum: Rationale for the opposite stereochemistry of the major monoadducts and interstrand crosslinks formed by mitomycin C and its decarbamoylated analogue at CpG steps in DNA and the effect of cytosine modification on reactivity (Organic and Biomolecular Chemistry (2012) 10 (1543-1552) DOI: 10.1039/C1OB06675G))

    Organic and Biomolecular Chemistry

  2. Rationale for the opposite stereochemistry of the major monoadducts and interstrand crosslinks formed by mitomycin C and its decarbamoylated analogue at CpG steps in DNA and the effect of cytosine modification on reactivity

    Organic and Biomolecular Chemistry, Vol. 10, Núm. 8, pp. 1543-1552

2011

  1. Synthesis, modeling and evaluation of 3′-(1-aryl-1H-tetrazol-5- ylamino)-substituted 3′-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors

    Organic and Biomolecular Chemistry, Vol. 9, Núm. 3, pp. 892-901

2010

  1. 3′-[4-Aryl-(1,2,3-triazol-1-yl)]-3′-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase

    Journal of Medicinal Chemistry, Vol. 53, Núm. 7, pp. 2902-2912

  2. Intramolecular cation-π interactions as the driving force to restrict the conformation of certain nucleosides

    Journal of Organic Chemistry, Vol. 75, Núm. 6, pp. 1974-1981

  3. PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity

    British Journal of Pharmacology, Vol. 161, Núm. 5, pp. 1099-1110

  4. Protein-protein interactions at an enzyme-substrate interface: Characterization of transient reaction intermediates throughout a full catalytic cycle of Escherichia coli thioredoxin reductase

    Proteins: Structure, Function and Bioinformatics, Vol. 78, Núm. 1, pp. 36-51

2009

  1. Human mitochondrial thymidine kinase is selectively inhibited by 3′-thiourea derivatives of β-thymidine: Identification of residues crucial for both inhibition and catalytic activity

    Molecular Pharmacology, Vol. 75, Núm. 5, pp. 1127-1136

  2. Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5′-O-tritylinosine (KIN59)

    Biochemical Pharmacology, Vol. 78, Núm. 3, pp. 231-240

  3. Molecular pharmacology and antitumor activity of Zalypsis® in several human cancer cell lines

    Biochemical Pharmacology, Vol. 78, Núm. 2, pp. 162-170

2008

  1. Estudios in silico de la afinidad de distintos ligandos por sus macromoleculas diana

    Estudios in silico de la afinidad de distintos ligandos por sus macromoleculas diana

  2. Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

    ChemMedChem, Vol. 3, Núm. 7, pp. 1083-1093

  3. Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): Present and future

    Medicinal Research Reviews, Vol. 28, Núm. 5, pp. 797-820

2007

  1. Antitumor activity, X-ray crystal structure, and DNA binding properties of thiocoraline A, a natural bisintercalating thiodepsipeptide

    Journal of Medicinal Chemistry, Vol. 50, Núm. 14, pp. 3322-3333

  2. Stepwise dissection and visualization of the catalytic mechanism of haloalkane dehalogenase LinB using molecular dynamics simulations and computer graphics

    Journal of Molecular Graphics and Modelling, Vol. 26, Núm. 3, pp. 643-651

2006

  1. N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors

    Journal of Medicinal Chemistry, Vol. 49, Núm. 26, pp. 7766-7773

2005

  1. Quantitative analysis of substrate specificity of haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26

    Biochemistry, Vol. 44, Núm. 9, pp. 3390-3401

  2. Role of stacking interactions in the binding sequence preferences of DNA bis-intercalators: Insight from thermodynamic integration free energy simulations

    Nucleic Acids Research, Vol. 33, Núm. 19, pp. 6214-6224