Publications by the researcher in collaboration with Pedro Alejandro Sánchez Murcia (40)

2024

  1. The repertoire of iron superoxide dismutases from Leishmania infantum as targets in the search for therapeutic agents against leishmaniasis

    Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 39, Núm. 1

2022

  1. Identification of 1,2,3-triazolium salt-based inhibitors of Leishmania infantum trypanothione disulfide reductase with enhanced antileishmanial potency in cellulo and increased selectivity

    European Journal of Medicinal Chemistry, Vol. 244

2021

  1. Efficient Dimerization Disruption of Leishmania infantum Trypanothione Reductase by Triazole-phenyl-thiazoles

    Journal of Medicinal Chemistry, Vol. 64, Núm. 9, pp. 6137-6160

2020

  1. A Supramolecular Stabilizer of the 14-3-3ζ/ERα Protein-Protein Interaction with a Synergistic Mode of Action

    Angewandte Chemie - International Edition, Vol. 59, Núm. 13, pp. 5284-5287

  2. Peptides mimicking the β7/β8 loop of HIV'1 reverse transcriptase p51 as “hotspot-targeted” dimerization inhibitors

    ACS Medicinal Chemistry Letters, Vol. 11, Núm. 5, pp. 811-817

2019

  1. Cold-induced aldimine bond cleavage by Tris in: Bacillus subtilis alanine racemase

    Organic and Biomolecular Chemistry, Vol. 17, Núm. 17, pp. 4350-4358

  2. Identification of NEK3 and MOK as novel targets for lithium

    Chemical Biology and Drug Design

  3. Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase

    ACS Infectious Diseases, Vol. 5, Núm. 6, pp. 873-891

  4. Reaction mechanism of nucleoside 2′-deoxyribosyltransferases: Free-energy landscape supports an oxocarbenium ion as the reaction intermediate

    Organic and Biomolecular Chemistry, Vol. 17, Núm. 34, pp. 7891-7899

  5. Unravelling the covalent binding of zampanolide and taccalonolide AJ to a minimalist representation of a human microtubule

    Journal of Computer-Aided Molecular Design, Vol. 33, Núm. 7, pp. 627-644

2018

  1. A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility

    Journal of Natural Products, Vol. 81, Núm. 3, pp. 524-533

  2. Characterization of an atypical, thermostable, organic solvent- and acid-tolerant 2′-deoxyribosyltransferase from Chroococcidiopsis thermalis

    Applied Microbiology and Biotechnology, Vol. 102, Núm. 16, pp. 6947-6957

  3. Engineering Erg10 Thiolase from Saccharomyces cerevisiae as a Synthetic Toolkit for the Production of Branched-Chain Alcohols

    Biochemistry, Vol. 57, Núm. 8, pp. 1338-1348

  4. Enzymatic Synthesis of Therapeutic Nucleosides using a Highly Versatile Purine Nucleoside 2’-DeoxyribosylTransferase from Trypanosoma brucei

    ChemCatChem, Vol. 10, Núm. 19, pp. 4406-4416

  5. Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability

    European Journal of Medicinal Chemistry, Vol. 149, pp. 238-247

2017

  1. 2′-Deoxyribosyltransferase from Leishmania mexicana, an efficient biocatalyst for one-pot, one-step synthesis of nucleosides from poorly soluble purine bases

    Applied Microbiology and Biotechnology, Vol. 101, Núm. 19, pp. 7187-7200

  2. First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity#

    European Journal of Medicinal Chemistry, Vol. 135, pp. 49-59

  3. Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides

    European Journal of Medicinal Chemistry, Vol. 140, pp. 615-623

  4. Making sense of the past: Hyperstability of ancestral thioredoxins explained by free energy simulations

    Physical Chemistry Chemical Physics, Vol. 19, Núm. 34, pp. 23239-23246

  5. Structural rationale for the cross-resistance of tumor cells bearing the A399V variant of elongation factor eEF1A1 to the structurally unrelated didemnin B, ternatin, nannocystin A and ansatrienin B

    Journal of Computer-Aided Molecular Design, Vol. 31, Núm. 10, pp. 915-928