Publikationen in Zusammenarbeit mit Forschern von KU Leuven (44)

2023

  1. Insertion of an Amphipathic Linker in a Tetrapodal Tryptophan Derivative Leads to a Novel and Highly Potent Entry Inhibitor of Enterovirus A71 Clinical Isolates

    International Journal of Molecular Sciences, Vol. 24, Núm. 4

2022

  1. A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro

    Pharmaceuticals, Vol. 15, Núm. 8

  2. Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors

    European Journal of Medicinal Chemistry, Vol. 237

2021

  1. Double Arylation of the Indole Side Chain of Tri- And Tetrapodal Tryptophan Derivatives Renders Highly Potent HIV-1 and EV-A71 Entry Inhibitors

    Journal of Medicinal Chemistry, Vol. 64, Núm. 14, pp. 10027-10046

  2. Multivalent Tryptophan- and Tyrosine-Containing [60]Fullerene Hexa-Adducts as Dual HIV and Enterovirus A71 Entry Inhibitors

    Chemistry - A European Journal, Vol. 27, Núm. 41, pp. 10700-10710

2020

  1. N-benzyl 4,4-disubstituted piperidines as a potent class of influenza H1N1 virus inhibitors showing a novel mechanism of hemagglutinin fusion peptide interaction

    European Journal of Medicinal Chemistry, Vol. 194

  2. Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors

    Journal of Medicinal Chemistry, Vol. 63, Núm. 1, pp. 349-368

2019

  1. Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus - A 71 capsid

    PLoS Pathogens, Vol. 15, Núm. 5

2018

  1. High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design

    Scientific Reports, Vol. 8, Núm. 1

2017

  1. Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes

    New England Journal of Medicine, Vol. 377, Núm. 13, pp. 1228-1239

2015

  1. Conservation of antiviral activity and improved selectivity in PMEO-DAPym upon pyrimidine to triazine scaffold hopping

    Antiviral Research, Vol. 122, pp. 64-68

  2. Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes

    New England Journal of Medicine, Vol. 373, Núm. 3, pp. 232-242

2014

  1. The pyrimidine nucleoside phosphorylase of mycoplasma hyorhinis and how it may affect nucleoside-based therapy

    Nucleosides, Nucleotides and Nucleic Acids, Vol. 33, Núm. 4-6, pp. 394-402

2012

  1. Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: Implications for the clinical efficacy of nucleoside analogues

    Biochemical Journal, Vol. 445, Núm. 1, pp. 113-123

  2. Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway

    Journal of Biological Chemistry, Vol. 287, Núm. 36, pp. 30444-30454

  3. Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications

    Current Pharmaceutical Design, Vol. 18, Núm. 20, pp. 2981-2994

2011

  1. Synthesis, modeling and evaluation of 3′-(1-aryl-1H-tetrazol-5- ylamino)-substituted 3′-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors

    Organic and Biomolecular Chemistry, Vol. 9, Núm. 3, pp. 892-901

2010

  1. 3′-[4-Aryl-(1,2,3-triazol-1-yl)]-3′-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase

    Journal of Medicinal Chemistry, Vol. 53, Núm. 7, pp. 2902-2912

2009

  1. Human mitochondrial thymidine kinase is selectively inhibited by 3′-thiourea derivatives of β-thymidine: Identification of residues crucial for both inhibition and catalytic activity

    Molecular Pharmacology, Vol. 75, Núm. 5, pp. 1127-1136

  2. Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5′-O-tritylinosine (KIN59)

    Biochemical Pharmacology, Vol. 78, Núm. 3, pp. 231-240