Vasculitis, arteritis de grandes arterias, enfermedad de Behçet enfermedad de Kawasaki
- Turrión Nieves, Ana Isabel
- Movasat, A.
- Álvarez de Mon Soto, Melchor
ISSN: 0304-5412
Year of publication: 2013
Issue Title: Enfermedades del sistema inmune (VI): vasculitis y miopatías inflamatorias
Series: 11
Issue: 33
Pages: 2029-2039
Type: Article
More publications in: Medicine: Programa de Formación Médica Continuada Acreditado
Abstract
Giant-cell arteritis and Takayasu's arteritis are medium- and large-vessel vasculitis. Their etiopathogenesis remains unknown. Both present a systemic clinical pattern with: deterioration of the general condition, increase in inflammatory acute-phase reactants and symptomatology result from locoregional changes in the affected vessels. Recent studies have reported increased expression of IL-6 and TNF-?. There is some evidence that biologic agents, especially TNF-? inhibitors (anti-TNF or tocilizumab), might be efficacious in patients with medium- and large-vessel vasculitis. Behçet and Kawasaki disease are vasculitis of the arteries and veins of any size. Behçet's disease is usually a multisystemic venulitis. In patients with poor prognosis, treatment with anti-TNF biological agents have proven to be effective. The major sequelae of Kawasaki disease are coronary artery aneurysms, early treatment with intravenous immunoglobulin and aspirin prevents their development.