Diseño y evaluación de estrategias vacunales frente a la leishmaniosis visceral y cutáneaoptimización del candidato poliantigénico HisAK70

  1. Martinez Rodrigo, Abel
Supervised by:
  1. Francisco Javier Carrión Herrero Director
  2. Gustavo Domínguez Bernal Director

Defence university: Universidad Complutense de Madrid

Fecha de defensa: 28 January 2021

Committee:
  1. Guadalupe Miró Corrales Chair
  2. María Teresa Gómez Muñoz Secretary
  3. Raquel Álvarez Velilla Committee member
  4. Carla Alexandra Soares Maia Committee member
  5. Antonio Jiménez Ruiz Committee member

Type: Thesis

Teseo: 154112 DIALNET lock_openDocta Complutense editor

Abstract

Leishmaniosis is a parasitic disease caused by different species of protozoa included in the genus Leishmania. It is classified as a neglected tropical disease, with incidence in different regions of the Mediterranean Basin and the Middle East, as well as in tropical and subtropical areas. In humans there are different clinical manifestation, depending on the Leishmania species involved, ranging from the appearance of local lesions, cutaneous leishmaniasis (CL) and mucocutaneous (MCL), to systemic involvement, visceral leishmaniasis (VL), and even death in the absence of adequate treatment. It should be noted that dogs are the main reservoir of L. infantum, the causal agent of human zoonotic VL, making it an important epidemiological agent...