Sarcoidosis
- Revenga Martínez, M.
- Blázquez Cañamero, M.A.
- Llop Vilatella, M.
ISSN: 0304-5412
Any de publicació: 2017
Sèrie: 12
Número: 27
Pàgines: 1560-1573
Tipus: Article
Altres publicacions en: Medicine: Programa de Formación Médica Continuada Acreditado
Resum
Introduction Sarcoidosis is a multisystemic disease affecting young adults with slight female predominance. Usually has bilateral hilar lymphadenopathy, pulmonary infiltrates, and eye and skin lesions. From an asymptomatic state to a chronic condition, with the possibility of causing severe clinical sequelae, deterioration of the quality of life, and even death. Aetiopathogenesis Of unknown aetiopathogenesis, will suggest that the exposure to one or several antigens, environmental, infectious or genetic, triggers an abnormal immune response in a genetically susceptible host. Diagnosis Definitive diagnosis of sarcoidosis requires a compatible clinical-radiological manifestations, histological evidence of non-caseating granulomas and exclusion of other granulomatous diseases. Treatment The basis of the treatment are the corticosteroids. Immunosuppressants may be used, as savers of corticosteroids, or second-line treatment, given its ineffectiveness, side effects, or the need for prolonged treatment. And as a third option, biological agents and even organ transplant.
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