Implicación del sustrato del receptor de Insulina-4 (IRS-4) en la invasividad del cáncer colorrectal

  1. M. Val Toledo Lobo
  2. Fernando Noguerales Fraguas
  3. María Encarnación Fernández Contreras
  4. Luis G. Guijarro
  5. Patricia Sanmartín Salinas
Séptimas Jornadas de Jóvenes Investigadores de la Universidad de Alcalá: Ciencias e Ingenierías
  1. Antonio Guerrero Ortega (coord.)
  2. Germán Ros Magán (coord.)
  3. Paloma Ruíz Benito (coord.)
  4. Francisco Pascual Vives (coord.)
  5. Cristina Tejedor Martínez (coord.)
  6. Vanessa Tabernero Magro (coord.)

Publisher: Editorial Universidad de Alcalá ; Universidad de Alcalá

ISBN: 978-84-17729-43-1

Year of publication: 2019

Pages: 115-123

Congress: Jornadas de Jóvenes Investigadores de la Universidad de Alcalá (7. 2019. Alcalá de Henares)

Type: Conference paper


Colorectal cancer is a leading cause of cancer death worldwide. Surgical resection and chemotherapy are the treatments of choice, however, the development of metastasis and chemotherapy resistance are the major causes of clinical failure in the treatment. Therefore, it is necessary the development of new biomarkers and therapeutic targets that can improve the prognosis and diagnosis of this disease. The Insulin Receptor Substrate- 4 (IRS-4) is a scaffold protein, with unique characteristics that make it different from the other family members and has an important role in promoting tumor growth. In this work, we analyze the involvement of IRS4 in CRC invasiveness.