"Cancer stem cells", un mecanismo de resistencia en cáncer de próstata
- Belén Sánchez Gómez
- Alicia Bort
- Irene de Miguel
- Pedro A. Mateos Gómez
- Nieves Rodríguez Henche
- Inés Díaz Laviada
- Antonio Guerrero Ortega (coord.)
- Germán Ros Magán (coord.)
- Paloma Ruíz Benito (coord.)
- Francisco Pascual Vives (coord.)
- Cristina Tejedor Martínez (coord.)
- Vanessa Tabernero Magro (coord.)
Publisher: Editorial Universidad de Alcalá ; Universidad de Alcalá
ISBN: 978-84-17729-43-1
Year of publication: 2019
Pages: 75-84
Congress: Jornadas de Jóvenes Investigadores de la Universidad de Alcalá (7. 2019. Alcalá de Henares)
Type: Conference paper
Abstract
Prostate cancer (PCa) is the second cause of cancer death in men because it can progress and become resistant to conventional therapies such as androgen deprivation therapy. Among the causes that can contribute to the failure of treatments highlight the epithelial-neuroendocrine transition (NED) and the presence of cancer stem cells (CSC). In this study, we have explored the mechanisms by which androgen withdrawal is implicated in the emergence of resistance in PCa. The LNCaP cells were cultured daily in absence of androgens, which caused an increase in the NED markers and the prostate specific antigen PSMA. This finding allowed us to validate a new stable cell line with NED (LNCaP-NE) that showed an increase in markers of resistance to drugs and CSC.