Estudio del papel de la DNA polimerasa Theta en la progresión del cáncer de próstata y su relevancia como diana terapéutica
- Irene de Miguel García
- Jose María Mora
- María Couto Muga
- Carolina Guerrero Amelín
- Belén Sánchez Gómez
- Alicia Bort
- Nieves Rodríguez Henche
- Inés Díaz Laviada
- Pedro A. Mateos Gómez
- Antonio Guerrero Ortega (ed. lit.)
- Germán Ros Magán (ed. lit.)
- Paloma Ruíz Benito (ed. lit.)
- Francisco Pascual Vives (ed. lit.)
- Cristina Tejedor Martínez (ed. lit.)
- Vanessa Tabernero Magro (ed. lit.)
Publisher: Editorial Universidad de Alcalá ; Universidad de Alcalá
ISBN: 978-84-18254-50-5
Year of publication: 2021
Pages: 39-50
Congress: Jornadas de Jóvenes Investigadores de la Universidad de Alcalá (8. 2021. Alcalá de Henares)
Type: Conference paper
Sustainable development goals
Abstract
Genomic integrity is endangered by damage incurred to DNA, but the most dangerous lesions are the double stranded breaks (DSBs). Therefore, eukaryotic cells have evolved robust mechanisms of DNA damage repair in order to avoid the accumulation of mutations and maintain genomic integrity. Among them, the alternative non-homologous end joining (A-NHEJ), involving the Polymerase Theta (POLθ), encoded by POLQ. Polθ is frequently overexpressed in human cancers and this overexpression is also correlate with a poor patient prognosis indicating that treatment of these tumors is less efficient. Our data and other’s suggest that that Polθ is also upregulated in prostate cancer and different cell lines require Polθ for survival. Our hypothesis is that the genetic alterations in prostate tumors would increase the usage of the Polθ mediated A-NHEJ repair in prostate cancer. Therefore, we propose to study whether its inhibition is relevant for the treatment of the most lethal tumours and previous stages avoiding resistance acquisition.