Diseño, interacción y síntesis de compuestos biológicamente activos ; Design, interaction and synthesis of bioactive compounds.
DISCOBAC
Instituto de Química Orgánica General
Madrid, EspañaPublicacións en colaboración con investigadores/as de Instituto de Química Orgánica General (67)
2024
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Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with In Vitro and In Vivo Activity in Neurodegenerative Diseases
Journal of Medicinal Chemistry, Vol. 67, Núm. 18, pp. 16533-16555
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Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors
ACS Chemical Neuroscience, Vol. 15, Núm. 18, pp. 3363-3383
2023
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Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment
International Journal of Molecular Sciences, Vol. 24, Núm. 11
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Straightforward Synthesis of Bis[(trifluoromethyl)sulfonyl]ethylated Isocoumarins from 2-Ethynylbenzoates
Journal of Organic Chemistry, Vol. 88, Núm. 11, pp. 7373-7380
2022
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N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases
Molecules, Vol. 27, Núm. 21
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The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents
ACS Pharmacology and Translational Science, Vol. 5, Núm. 11, pp. 1097-1108
2021
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Pd-catalyzed C(sp3)-C(sp) bond formation in iodocyclobutenes
Chemical Communications, Vol. 57, Núm. 68, pp. 8456-8459
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Privileged quinolylnitrones for the combined therapy of ischemic stroke and alzheimer’s disease
Pharmaceuticals, Vol. 14, Núm. 9
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Studies on the affinity of 6-[(: N -(cyclo)aminoalkyl)oxy]-4 H -chromen-4-ones for sigma 1/2 receptors
RSC Medicinal Chemistry, Vol. 12, Núm. 6, pp. 1000-1004
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Synthesis and Biological Assessment of PyrimidoTacrines as Promising Agents for Alzheimer's Disease Therapy
ChemistrySelect, Vol. 6, Núm. 37, pp. 9975-9980
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Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments
Chemical Record, Vol. 21, Núm. 1, pp. 162-174
2020
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Acetylcholinesterase inhibition of diversely functionalized quinolinones for alzheimer’s disease therapy
International Journal of Molecular Sciences, Vol. 21, Núm. 11, pp. 1-20
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Automated Synthesis of New Quinoxalinetacrines
ChemistrySelect, Vol. 5, Núm. 21, pp. 6491-6493
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In Vitro and in Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases
ACS Chemical Neuroscience, Vol. 11, Núm. 22, pp. 3793-3801
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Synthesis of hantzsch adducts as cholinesterases and calcium flux inhibitors, antioxidants and neuroprotectives
International Journal of Molecular Sciences, Vol. 21, Núm. 20, pp. 1-19
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Triazolopyridopyrimidine: A new scaffold for dual-target small molecules for Alzheimer's disease therapy
Molecules, Vol. 25, Núm. 14
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Triflyl-assisted reductive Pd-catalyzed Tsuji-Trost type reaction
Chemical Communications, Vol. 56, Núm. 45, pp. 6070-6073
2019
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Chromenones as Multineurotargeting Inhibitors of Human Enzymes
ACS Omega, Vol. 4, Núm. 26, pp. 22161-22168
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Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 34, Núm. 1, pp. 479-489
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Multi-target 1,4-dihydropyridines showing calcium channel blockade and antioxidant capacity for Alzheimer's disease therapy
Bioorganic Chemistry, Vol. 91