Publicacións en colaboración con investigadores/as de Instituto de Química Orgánica General (32)

2025

  1. 2-{N-[ω-(1-Benzylpiperidin-4-yl)alkyl]amino}-6-[(prop-2-yn-1-yl)amino]pyridine-3,5-dicarbonitriles Showing High Affinity for σ1/2 Receptors

    International Journal of Molecular Sciences, Vol. 26, Núm. 3

  2. Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative

    Synlett, Vol. 36, Núm. 16, pp. 2655-2660

  3. Copper-mediated divergent reactivity of allene-tethered carbamates under radical conditions

    Organic Letters, Vol. 27, Núm. 25, pp. 6823-6829

  4. Generation and validation of a novel multitarget small molecule in glioblastoma

    Cell Death and Disease, Vol. 16, Núm. 1

  5. Multicomponent Synthesis of Multi-Target Quinazolines Modulating Cholinesterase, Oxidative Stress, and Amyloid Aggregation Activities for the Therapy of Alzheimer’s Disease

    Molecules, Vol. 30, Núm. 19

  6. N-Methyl-N-((1-methyl-5-(3-(piperidin-1-yl)propoxy)-1H-benzo[d]imidazol-2-yl)methyl)prop-2-yn-1-amine (MBA-159), a new multitarget small molecule for the therapy of Alzheimer's disease

    Biomedicine and Pharmacotherapy, Vol. 192

2024

  1. Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with In Vitro and In Vivo Activity in Neurodegenerative Diseases

    Journal of Medicinal Chemistry, Vol. 67, Núm. 18, pp. 16533-16555

  2. Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors

    ACS Chemical Neuroscience, Vol. 15, Núm. 18, pp. 3363-3383

2023

  1. Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment

    International Journal of Molecular Sciences, Vol. 24, Núm. 11

  2. Straightforward Synthesis of Bis[(trifluoromethyl)sulfonyl]ethylated Isocoumarins from 2-Ethynylbenzoates

    Journal of Organic Chemistry, Vol. 88, Núm. 11, pp. 7373-7380

2022

  1. N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases

    Molecules, Vol. 27, Núm. 21

  2. The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents

    ACS Pharmacology and Translational Science, Vol. 5, Núm. 11, pp. 1097-1108

2021

  1. Pd-catalyzed C(sp3)-C(sp) bond formation in iodocyclobutenes

    Chemical Communications, Vol. 57, Núm. 68, pp. 8456-8459

  2. Privileged quinolylnitrones for the combined therapy of ischemic stroke and alzheimer’s disease

    Pharmaceuticals, Vol. 14, Núm. 9

  3. Studies on the affinity of 6-[(: N -(cyclo)aminoalkyl)oxy]-4 H -chromen-4-ones for sigma 1/2 receptors

    RSC Medicinal Chemistry, Vol. 12, Núm. 6, pp. 1000-1004

  4. Synthesis and Biological Assessment of PyrimidoTacrines as Promising Agents for Alzheimer's Disease Therapy

    ChemistrySelect, Vol. 6, Núm. 37, pp. 9975-9980

  5. Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments

    Chemical Record, Vol. 21, Núm. 1, pp. 162-174

2020

  1. Acetylcholinesterase inhibition of diversely functionalized quinolinones for alzheimer’s disease therapy

    International Journal of Molecular Sciences, Vol. 21, Núm. 11, pp. 1-20

  2. Automated Synthesis of New Quinoxalinetacrines

    ChemistrySelect, Vol. 5, Núm. 21, pp. 6491-6493

  3. In Vitro and in Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases

    ACS Chemical Neuroscience, Vol. 11, Núm. 22, pp. 3793-3801