Physicochemical considerations of ibuprofen and its sodium salt in different solvents
- M. Ángeles Peña Fernández 1
- Mathew B 1
- Norma Sofía Torres Pabón 1
- 1 Departamento de Ciencias Biomédicas, U.D. Farmacia y Tecnología Farmacéutica. Universidad de Alcalá. Alcalá de Henares. Madrid.
ISSN: 2660-6356
Ano de publicación: 2021
Título do exemplar: XV CONGRESO DE LA SOCIEDAD ESPAÑOLA DE FARMACIA INDUSTRIA Y GALÉNICA
Volume: 2
Número: 2
Páxinas: 170-172
Tipo: Artigo
Outras publicacións en: RESCIFAR Revista Española de Ciencias Farmacéuticas
Resumo
From a pharmaceutical point of view, one of the most significant actions is the physicochemical information through characterization of the pharmacologically active molecules. This paper deals about characterization of some aspects of racemic compound (R,S)-(±)-ibuprofen or (R,S)- (±)-2-(4-isobutylphenyl) propionic acid (IBP) and (R,S)-(±)-ibuprofen salt, ibuprofen (IBPNa) [1-3], using solvent precipitation method with different types of instrumental analysis, to describe the possible differences detected respect crystallization, polymorphic conversion, desolvation or dehydration.