Protocolo diagnóstico y terapéutico de las poliglobulias
- García Ramírez, P. 1
- Villafuerte Gutiérrez, P. 1
- 1 Servicio de Hematología y Hemoterapia, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España
ISSN: 0304-5412
Year of publication: 2020
Series: 13
Issue: 21
Pages: 1224-1228
Type: Article
More publications in: Medicine: Programa de Formación Médica Continuada Acreditado
Sustainable development goals
Abstract
Polycythemia or erythrocytosis refers to an increase in hemoglobin and hematocrit concentration in peripheral blood. The erythopoietin, produced in 95% of renal cells, is in charge of erythropoiesis regulation due to hypoxia and is elevated in secondary erythrocytosis. The most important primary erythrocytosis is polycythemia vera, a chronic myeloproliferative neoplasm that produces erythrocytosis independently of erythropoietin due to a mutation in erythroid progenitor cells. A diagnosis is established based on an increase in hemoglobin above 16.5 g/dl in men and 16 g/dl in women. An etiological diagnosis is fundamental for an appropriate management of the patient.
Bibliographic References
- Lee G, Arcasoy MO. The clinical and laboratory evaluation of the patient with erythrocytosis. Eur J Intern Med. 2015;26(5):297-302.
- Keohane C, McMullin MF, Harrison C. The diagnosis and mana-gement of erythrocytosis. BMJ. 2013;347:f6667.
- Swerdlow SH, Campo E, Harris N. WHO Classification of Tu-mours of Haematopoietic and Lymphoid Tissues, revised. 4th ed. Inter-national Agency for Research on Cancer (IARC), Lyon; 2017.Carpeta 08_PROT_MEDICINE_21 (1224-1228).indd 122817/11/20 13:31
- Arrizabalaga B. Eritrocitosis secundarias adquiridas. Eritrocitosis idiopática. Eritropatología. Barcelona: Ambos Marketing; 2017. p 501-13.
- Bento C, Magalhaes T, Ribeiro ML. Eritrocitosis congénita. Eritro-patología. Barcelona: Ambos Marketing; 2017; 515-27.
- McMullin MF. Investigation and Management of Erythrocytosis. Curr Hematol Malig Rep. 2016;11:342-7