Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway

  1. Balzarini, J.
  2. Gago, F.
  3. Kulik, W.
  4. Van Kuilenburg, A.B.P.
  5. Karlsson, A.
  6. Peterson, M.A.
  7. Robins, M.J.
Revista:
Journal of Biological Chemistry

ISSN: 0021-9258,  1083-351X

Any de publicació: 2012

Volum: 287

Número: 36

Pàgines: 30444-30454

Tipus: Article

DOI: 10.1074/JBC.M112.378091 GOOGLE SCHOLAR lock_openAccés obert editor
Font de les dades: Scopus