Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway

  1. Balzarini, J.
  2. Gago, F.
  3. Kulik, W.
  4. Van Kuilenburg, A.B.P.
  5. Karlsson, A.
  6. Peterson, M.A.
  7. Robins, M.J.
Aldizkaria:
Journal of Biological Chemistry

ISSN: 0021-9258,  1083-351X

Argitalpen urtea: 2012

Alea: 287

Zenbakia: 36

Orrialdeak: 30444-30454

Mota: Artikulua

DOI: 10.1074/JBC.M112.378091 GOOGLE SCHOLAR lock_openSarbide irekia editor
Datuen iturria: Scopus