Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway

1. Balzarini, J.
2. Gago, F.
3. Kulik, W.
4. Van Kuilenburg, A.B.P.
5. Karlsson, A.
6. Peterson, M.A.
7. Robins, M.J.

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DOI: 10.1074/JBC.M112.378091 GOOGLE SCHOLAR lock_openOpen access editor

Data source: Scopus