Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway

  1. Balzarini, J.
  2. Gago, F.
  3. Kulik, W.
  4. Van Kuilenburg, A.B.P.
  5. Karlsson, A.
  6. Peterson, M.A.
  7. Robins, M.J.
Zeitschrift:
Journal of Biological Chemistry

ISSN: 0021-9258,  1083-351X

Datum der Publikation: 2012

Ausgabe: 287

Nummer: 36

Seiten: 30444-30454

Art: Artikel

DOI: 10.1074/JBC.M112.378091 GOOGLE SCHOLAR lock_openOpen Access editor
Datenquelle: Scopus