Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway

  1. Balzarini, J.
  2. Gago, F.
  3. Kulik, W.
  4. Van Kuilenburg, A.B.P.
  5. Karlsson, A.
  6. Peterson, M.A.
  7. Robins, M.J.
Revue:
Journal of Biological Chemistry

ISSN: 0021-9258,  1083-351X

Année de publication: 2012

Volumen: 287

Número: 36

Pages: 30444-30454

Type: Article

DOI: 10.1074/JBC.M112.378091 GOOGLE SCHOLAR lock_openAccès ouvert editor
La source de données: Scopus